外周血NK细胞与原发免疫性血小板减少症相关性的Meta分析  

Meta-analysis of the Correlation Between Peripheral Blood NK Cells and Primary Immune Thrombocytopenia

作　　者：李晓靖 周永明[1] 李洋 朱文伟[1] LI Xiao-jing;ZHOU Yong-ming;LI Yang;ZHU Wen-wei(Department of Hematology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院血液科,上海200437

出　　处：《医学信息》2024年第1期72-77,共6页Journal of Medical Information

基　　金：国家自然科学基金面上项目(编号:81973798);上海市临床重点专科建设项目(编号:shslczdzk05201);周永明全国名老中医药专家传承工作室(编号:国中医药人教函[2022]75号);上海中医药大学名老中医药专家学术经验研究工作室建设项目(编号:SZYMZYGZS4018)。

摘　　要：目的系统评价外周血自然杀伤(NK)细胞与原发免疫性血小板减少症(ITP)的相关性。方法全面检索PubMed、Springer Link、OVID、中国期刊全文数据库(CNKI)、维普中文科技期刊全文数据库(VIP)、中国生物医学文献服务系统(Sino Med)、万方医药期刊数据库(WAN FANG)等,查找关于NK细胞与ITP相关的研究,利用ReviewManager 5.3软件对纳入的研究进行Meta分析。结果最终纳入7项病例对照研究,共有514例研究对象,其中ITP组302例,对照组212例。Meta分析结果显示外周血NK细胞水平与ITP之间有显著的相关性(MD=-5.58,95%CI:-8.00~-3.15,P<0.00001);亚群分析结果显示外周血NK细胞水平与新诊断ITP存在明显相关性(MD=-4.89,95%CI:-9.39~-0.39,P=0.03)。结论外周血NK细胞水平与ITP之间有显著的相关性,靶向异常的NK细胞可能对ITP的发生、发展具有影响,为其治疗方案提供了理论基础。Objective To systematically evaluate the correlation between peripheral blood natural killer(NK)cells and primary immune thrombocytopenia(ITP).Methods Pub Med,Springer Link,OVID,China national knowledge infrastructure(CNKI),VIP Chinese Sci-tech Periodicals(VIP),China Biomedical Literature Service System(Sino Med),Wanfang Medical Periodicals(WAN FANG)were searched comprehensively to find the studies on the relationship between NK cells and ITP.Meta-analysis was performed on the included studies using Review Manager 5.3 software.Results Finally,7 case-control studies were included,with a total of 514 subjects,including 302 in the ITP group and 212 in the control group.The results of Meta-analysis showed that there was a significant correlation between peripheral blood NK cell level and ITP(MD=-5.58,95%CI:-8.00 to-3.15,P<0.00001).The results of subgroup analysis showed that the level of NK cells in peripheral blood was significantly correlated with the newly diagnosed ITP(MD=-4.89,95%CI:-9.39 to-0.39,P=0.03).Conclusion There is a significant correlation between peripheral blood NK cell level and ITP.Targeted abnormal NK cells may have an impact on the occurrence and development of ITP,which provides a theoretical basis for its treatment plan.

关 键 词：NK细胞 原发免疫性血小板减少症 免疫耐受 

分 类 号：R593.2[医药卫生—内科学]