早期IL-12p70、CAR、PCT联合检测对急性胰腺炎病情严重程度的预测价值  

Predictive Value of Early Combined Detection of IL-12p70,CAR and PCT for the Severity of Acute Pancreatitis

作　　者：罗辉黄 高明[1] 尹纯林[1] 孙远松 王召华[1] 颜锡洋 LUO Hui-huang;GAO Ming;YIN Chun-lin;SUN Yuan-song;WANG Zhao-hua;YAN Xi-yang(Department of Emergency Surgery,the Second Hospital of Anhui Medical University,Hefei 230601,Anhui,China)

机构地区：[1]安徽医科大学第二附属医院急诊外科,安徽合肥230601

出　　处：《医学信息》2024年第1期115-119,共5页Journal of Medical Information

基　　金：安徽医科大学校科学研究基金资助项目(编号:2020xkj192)。

摘　　要：目的探讨早期白介素12p70(IL-12p70)、C反应蛋白与血清白蛋白比值(CAR)、降钙素原(PCT)联合检测与急性胰腺炎(AP)患者病情严重度的相关性及对非轻症胰腺炎的早期预测效能。方法选取我院急诊外科2021年11月-2022年5月收治的102例AP患者的临床资料进行回顾性分析,依照修订后的亚特兰大分类将其分为轻症组(48例)和非轻症组(54例),比较两组入院时IL-12p70、CAR、PCT水平,通过受试者工作曲线(ROC)及相关性分析探究上述指标早期联合检测对AP病情严重程度的预测效能。结果两组性别、发病原因、年龄、血压、BMI、S-AMY、Ca2+、WBC比较,差异无统计学意义(P>0.05);非轻症组入院时的IL-12p70、CAR、PCT水平均高于轻症组(P<0.05);ROC曲线显示,IL-12p70、CAR、PCT早期预测非轻症AP发生的曲线下面积分别为0.866、0.762、0.927,三者并行检测可以将检测的灵敏度提升到0.996,特异度达0.998。相关性分析显示,早期IL-12p70、CAR、PCT三项指标与改良CT严重指数评分(MCTSI)呈正相关(r=0.603、0.420、0.669)。结论早期检测IL-12p70、CAR、PCT在AP患者病情严重程度的预测中均有一定的临床价值,且三种方法联合使用具有更好的预测效果。Objective To investigate the correlation between the early combined detection of interleukin 12p70(IL-12p70),C-reactive protein/albumin ratio(CAR)and procalcitonin(PCT)and the severity of acute pancreatitis(AP)and its early predictive efficacy for non-mild pancreatitis.Methods The clinical data of 102 patients with AP admitted to the emergency surgery department of our hospital from November 2021 to May 2022 were retrospectively analyzed.According to the revised Atlanta classification,they were divided into mild group(48 patients)and non-mild group(54 patients).The levels of IL-12p70,CAR and PCT at admission were compared between the two groups.The receiver operating curve(ROC)and correlation analysis were used to explore the predictive efficacy of early combined detection of the above indicators on the severity of AP.Results There was no significant difference in gender,cause of disease,age,blood pressure,BMI,S-AMY,Ca2+and WBC between the two groups(P>0.05).The levels of IL-12 p70,CAR and PCT in the non-mild group were higher than those in the mild group(P<0.05).The ROC curve showed that the areas under the curve of IL-12p70,CAR,and PCT for early prediction of non-mild AP were 0.866,0.762,and 0.927,respectively.Parallel detection of the three could increase the sensitivity of the detection to 0.996,and the specificity was 0.998.Correlation analysis showed that early IL-12p70,CAR and PCT were positively correlated with modified CT severity index score(MCTSI)(r=0.603,0.420,0.669).Conclusion Early detection of IL-12p70,CAR and PCT has certain clinical value in predicting the severity of AP patients,and the combined use of the three methods has a better predictive effect.

关 键 词：急性胰腺炎 白介素12p70 C反应蛋白与血清白蛋白比值 降钙素原 

分 类 号：R657.51[医药卫生—外科学]