交联羧甲基-β-环糊精聚合物修饰的Fe_(3) O_(4)磁性纳米粒子对盐酸阿霉素的负载和释放研究  

Investigation of Loading and Release Behaviors of Carboxymethyl-β-cyclodextrin Polymer Modified Fe_(3) O_(4) Magnetic Nanoparticles as Drug Carriers for Doxorubicin

作　　者：弓韬[1] 王晓宇 朱惠瑞 牛雨婷 李晓宁 李美宁[1] 常冰梅[1] 郭睿[1] GONG Tao;WANG Xiao-yu;ZHU Hui-rui;NIU Yu-ting;LI Xiao-ning;LI Mei-ning;CHANG Bing-mei;GUO Rui(Basic Medical College of Shanxi Medical University,Shanxi Taiyuan 030001,China)

机构地区：[1]山西医科大学基础医学院,山西太原030001

出　　处：《广州化工》2023年第15期36-38,52,共4页GuangZhou Chemical Industry

摘　　要：采用共沉淀法制备了交联羧甲基-β-环糊精聚合物修饰的Fe_(3) O_(4)磁性纳米粒子(MNPs@CDP),将其作为药物载体负载抗癌药物盐酸阿霉素(DOX),通过MTT实验来评估MNPs@CDP的生物相容性和吸附DOX后复合物(MNPs@CDP/DOX)的细胞毒性,并通过荧光成像技术观察了MNPs@CDP/DOX中DOX在HepG2肝癌细胞中的释放情况。结果表明MNPs@CDP在小于30 mg/mL的浓度范围内表现出了较好的生物相容性,并且MNPs@CDP/DOX和HepG2细胞共培养4 h后能够在细胞中释放大量药物,并能够有效杀死癌细胞。Cross-linked carboxymethyl-β-cyclodextrin polymer modified Fe_(3) O_(4) magnetic nanoparticles(MNPs@CDP)were prepared by co-precipitation method and used as drug carrier to load doxorubicin hydrochloride(DOX).The MTT method was used to investigate the biocompatibility of MNPS@CDPs and the cytotoxicity of MNPs@CDP/DOX.The release behavior of DOX at MNPs@CDP/DOX in the HepG2 cells was observed by fluorescence imaging.The results showed that the drug carrier MNPs@CDP had good biocompatibility in the concentration range of less than 30 mg/mL.The fluorescence image showed large amount of DOX at MNPs@CDP/DOX could release in the HepG2 cell after co-culture 4 h.

关 键 词：Fe_(3)O_(4)磁性纳米粒子 阿霉素 药物载体 

分 类 号：TB383[一般工业技术—材料科学与工程]