金银花化学成分的分离与鉴定  

Isolation and Identification of Chemical Constituents of Lonicerae Japonicae Flos

作　　者：陆远 杨然 张研 王莹[1] 陈芳 傅亚楠 张永清[1] LU Yuan;YANG Ran;ZHANG Yan;WANG Ying;CHEN Fang;FU Ya-nan;ZHANG Yong-qing(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学药学院,山东济南250355

出　　处：《中药材》2023年第4期866-870,共5页Journal of Chinese Medicinal Materials

基　　金：山东省高校中药质量控制与全产业链建设协同创新中心资助项目(CYLXTCX2021-16,13);山东省重点研发计划项目(2021CXGC010510);国家现代农业产业技术体系(CARS-21);山东中医药大学大学生创新创业训练计划项目(2021041);泰山产业领军人才工程专项经费(tscy20200410)。

摘　　要：目的:对金银花中的化学成分进行研究。方法:运用大孔树脂柱色谱、正相硅胶柱色谱、半制备高效液相等技术进行分离纯化,根据理化性质及波谱数据鉴定化合物的结构。结果:从金银花醇提物中分离得到10个化合物,分别鉴定为:7-dioxolanylsecologanin B(1)、断马钱子苷二甲基缩醛(2)、(7R)-secologain n-butyl methyl acetal(3)、(7S)-secologain n-butyl methyl acetal(4)、断马钱子苷半缩醛内酯(5)、表断马钱子苷半缩醛内酯(6)、7-O-ethyl sweroside(7)、断马钱子苷(8)、methyl dioxindile-3-acetae(9)、ethyl dioxindile-3-acetae(10)。结论:其中,化合物1为新化合物,化合物9、10为首次从忍冬属植物中分离得到。Objective:To study the chemical constituents of Lonicerae Japonicae Flos.Methods:The compounds were isolated and purified by macroporous resin column,silica gel column and semi⁃prepared high performance liquid chromatography,the structures were identified according to the physicochemical properties and spectral data.Results:Ten compounds were isolated and identified as 7⁃dioxo⁃lanylsecologanin B(1),secologanin dimethyl acetal(2),(7R)⁃secologainn⁃butyl methyl acetal(3),(7S)⁃secologainn⁃butyl methyl acetal(4),vogeloside(5),7⁃epi⁃vogeloside(6),7⁃O⁃ethyl sweroside(7),secologanin(8),methyl dioxindile⁃3⁃acetae(9),ethyl dioxin⁃dile⁃3⁃acetae(10),respectively.Conclusion:Among them,compound 1 is a new compound,and compounds 9,10 are isolated fromLoni⁃ceragenus for the first time.

关 键 词：金银花 化学成分 7-Dioxolanylsecologanin B Methyl dioxindile-3-acetae Ethyl dioxindile-3-acetae 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]