贵州金丝桃乙酸乙酯部位化学成分研究  

Chemical Constituents from Ethyl Acetate Fraction of Hypericum kouytchense

作　　者：周献冬 林亲雄[1] 杨新洲[1] ZHOU Xian-dong;LIN Qin-xiong;YANG Xin-zhou(College of Pharmacy,South-Central Minzu University,Wuhan 430074,China)

机构地区：[1]中南民族大学药学院,湖北武汉430074

出　　处：《中药材》2023年第4期886-891,共6页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金面上项目(81774000)。

摘　　要：目的:研究贵州金丝桃Hypericum kouytchense Lévl.中的化学成分。方法:综合应用多种分离手段对贵州金丝桃地上部分醇提物的乙酸乙酯部位进行分离纯化,运用现代波谱方法鉴定结构。结果:从贵州金丝桃地上部分醇提物的乙酸乙酯部位中分离得到16个化合物,分别鉴定为:uraloidin A(1)、uralione R(2)、attenuatumione G(3)、uralione D(4)、tomoeone A(5)、tomoeone B(6)、tomoeone C(7)、chipericumin E(8)、calycinoxanthon D(9)、hyperpatulol D(10)、hyperpatulol C(11)、sampsonol C(12)、hyperhenone I(13)、1,3,5-三羟基-8-异戊烯基氧杂蒽酮(14)、1,3,7-三羟基-2-异戊烯基氧杂蒽酮(15)、pulverulentone B(16)。结论:以上16个化合物均为首次从该植物中分离得到。Objective:To study the chemical constituents ofHypericum kouytchense.Methods:The various chromatographic tech⁃niques were used to isolate and purify the ethyl acetate extract of the ethanol extract from the aboveground part ofHypericum kouytch⁃ense.The structures of the compounds were identified by modern spectroscopic methods.Results:16 compounds were isolated from the ethyl acetate fraction of the ethanol extract from the aboveground part ofHypericum kouytchenseand identified as uraloidin A(1),uralione R(2),attenuatumione G(3),uralione D(4),tomoeone A(5),tomoeone B(6),tomoeone C(7),chipericumin E(8),calyci⁃noxanthon D(9),hyperpatulol D(10),hyperpatulol C(11),sampsonol C(12),hyperhenone I(13),1,3,5⁃trihydroxy⁃8⁃isoprenylxan⁃thone(14),1,3,7⁃trihydroxy⁃2⁃(3⁃methylbut⁃2⁃enyl)⁃xanthone(15),pulverulentone B(16),respectively.Conclusion:All compounds are isolated fromHypericum kouytchensefor the first time.

关 键 词：贵州金丝桃 化学成分 多环多异戊烯基取代间苯三酚衍生物 氧杂蒽酮 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]