绒毛膜羊膜炎:亚临床感染与临床结局  

Subclinical chorioamnionitis and clinical out⁃come

作　　者：盛超[1] 王志坚[1] SHENG Chao;WANG Zhi-jian(Department of Obstetrics and Gynecology,Nanfang Hospital,South-ern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院妇产科,广东广州510515

出　　处：《中国实用妇科与产科杂志》2023年第12期1189-1192,共4页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：国家重点研发计划(2022YFC2704504);国家自然科学基金(82271709);广东省自然科学基金(2023A1515010207,2023A1515012094)。

摘　　要：亚临床绒毛膜羊膜炎是指仅绒毛膜和(或)羊膜病理出现炎性改变,但无临床症状。亚临床绒毛膜羊膜炎更易进展为临床绒毛膜羊膜炎,即宫内感染。下生殖道逆行感染是其最主要的感染途径,最常见的病原菌是支原体。多个研究发现,亚临床绒毛膜羊膜炎增加了母儿不良结局(如:小于34孕周的早产、早产胎膜早破、无症状短子宫颈、新生儿脓毒血症、慢性肺病和脑瘫)的发生风险。早期识别和快速诊断亚临床绒毛膜羊膜炎,精准指导母儿早期感染的监测和抗生素的使用,将有助于降低母儿并发症的发生率。Subclinical chorioamnionitis(CAM),which is defined as inflammation of the chorionic membrane and/or amniotic membrane without any clinical signs of CAM.Subclinical CAM is more likely to develop to clinical CAM,or intrauterine infection.Ascending microbial invasion from the lower genital tract appears to be the most frequent pathway for intra-amniotic infection.The most frequent microorganisms found in the amniotic cavity are genital mycoplasmas.Multiple studies have already found that subclinical CAM was associated with preterm birth within 34 weeks of ges⁃tation,preterm premature rupture of membranes,as⁃ymptomatic short cervix,neontal sepsis,chronic lung disease,and cerebral palsy.Early identification and rapid diagnosis of subclinical CAM can accurately guide maternal and fetal infection monitoring and an⁃tibiotic to decrease perinatal complications.

关 键 词：亚临床绒毛膜羊膜炎 早产 早产胎膜早破 新生儿脓毒血症 脑瘫 

分 类 号：R714.43[医药卫生—妇产科学]