壳聚糖纳米技术的加减润肌膏治疗寻常型银屑病血燥证疗效观察  

Efficacy of modified moisturizing muscle ointment based on chitosan nanotechnology on psoriasis vulgaris of blood dryness syndrome

作　　者：邱玥 卢春茜 李冠汝 孙丽蕴[1] QIU Yue;LU Chunqian;LI Guanru;SUN Liyun(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Beijing Miyun District Hospital of Traditional Chinese Medicine,Beijing 101500,China;Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine,Beijing 101300,China)

机构地区：[1]首都医科大学附属北京中医医院,北京100010 [2]北京市密云区中医医院,北京101500 [3]北京中医医院顺义医院,北京101300

出　　处：《现代中西医结合杂志》2023年第21期2935-2940,共6页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：国家自然科学基金项目(81774309);第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]1号);北京市优秀人才培养资助项目(2018000092582G364)。

摘　　要：目的评价壳聚糖纳米技术的加减润肌膏治疗寻常型银屑病血燥证的临床疗效及安全性。方法选取2021年1月—2022年1月在首都医科大学附属北京中医医院皮肤科门诊就诊的40例寻常型银屑病血燥证患者,按1∶1比例将患者随机分为对照组和治疗组。2组患者均口服养血解毒汤,治疗组同时外用壳聚糖纳米颗粒包裹的加减润肌膏,对照组外用壳聚糖纳米颗粒包裹的安慰剂药膏,2组疗程均为8周,每2周随访1次,比较2组皮损面积与严重程度指数(PASI)评分、体表面积(BAS)评分、银屑病瘙痒(VAS)评分、中医症状评分、皮肤屏障-水分评分、皮肤屏障-油脂评分、皮肤病生活质量(DLQI)评分及临床疗效。结果治疗组19例、对照组18例患者完成研究。治疗8周末,治疗组PASI评分、BAS评分、VAS评分、中医症状评分、皮肤屏障-水分评分、皮肤屏障-油脂评分、DLQI评分改善情况均明显优于对照组(P均<0.05)。治疗组显效率为84.2%(16/19),总有效率为94.7%(18/19);对照组显效率为50.0%(9/18),总有效率为83.3%(15/18),治疗组显效率明显高于对照组(P均<0.05),2组总有效率比较差异无统计学意义(P>0.05)。治疗组94.7%(18/19)的患者达到PASI50,对照组66.7%(12/18)的患者达到PASI50,治疗组高于对照组(P<0.05);治疗组47.4%(9/19)的患者达到PASI75,对照组16.7%(3/18)的患者达到PASI75,治疗组高于对照组(P<0.05)。所有受试者均未见明显不良反应。结论基于壳聚糖纳米技术的加减润肌膏治疗寻常型银屑病血燥证安全有效,是中医药在外用方面的一种创新性的尝试。Objective It is to evaluate the clinical efficacy and safety of modified cmoisturizing muscle ointment based on chitosan nanotechnology on psoriasis vulgaris of blood dryness syndrome.Methods Forty patients with psoriasis vulgaris of blood dryness syndrome treated at outpatient clinic of dermatology department of Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University from January 2021 to January 2022 were selected,and divided into control group and treatment group,with 20 cases in each group.The patients of the two groups were treated with the decoction for nourishing blood and eliminating toxin orally,and the treatment group was treated with modified cmoisturizing muscle ointment encapsulated in chitosan nanoparticles by external application,and the control group was treated with chitosan nanoparticle-coated placebo ointment,both groups were treated for 8 weeks,followed-up every 2 weeks.The scores of psoriasis area and severity index(PASI),scores of body surface area(BAS),scors of psoriasis itch(VAS),scores of TCM symptom,scores of skin barrier-moisture,scores of skin barrier-oil,scores of dermatology life quality index(DLQI)and clinical efficacy of the two groups were compared.Results Nineteen patients in the treatment group and 18 patients in the control group completed the study.At the end of 8 weekends of treatment,the improvements of PASI score,BAS score,VAS score,TCM symptom score,skin-barrier-hydration score,skin-barrier-oil score,and DLQI score of the treatment group were significantly better than those of the control group(all P<0.05).The excellent effective rate of the treatment group was 84.2%(16/19),and the total effective rate was 94.7%(18/19);the excellent effective rate of the control group was 50.0%(9/18),and the total effective rate was 83.3%(15/18),and the excellent effective rate of the treatment group was significantly higher than that of the control group(P<0.05),the difference in the total effective rate was not statistically significant between the two gr

关 键 词：寻常型银屑病 血燥证 壳聚糖纳米技术 中医药外治 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]