载脂蛋白A功能研究进展  

Research Progress on the Function of Apolipoprotein A

作　　者：李娜 王林霞 武冬民 王耀勇 LI Na;WANG Linxia;WU Dongmin;WANG Yaoyong(Fenyang College of Shanxi Medical University,Fenyang 032200,China;Department of Respiratory and Critical Care Medicine,Fenyang Hospital of Shanxi Province,Fenyang 032200,China)

机构地区：[1]山西医科大学汾阳学院,山西省汾阳市032200 [2]山西省汾阳医院呼吸与危重症医学科,山西省汾阳市032200

出　　处：《实用心脑肺血管病杂志》2024年第1期122-128,共7页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：山西省卫健委医学重点科研攻关专项项目(2020XM30);吕梁市引进高层次科技人才重点研发项目(2021RC-2-31)。

摘　　要：载脂蛋白(Apo)能与血浆脂质结合并形成脂蛋白,是决定脂蛋白结构、功能和代谢的核心组分。ApoA是最重要的Apo,其对脂质代谢的作用机制及与心血管疾病之间的关系一直是研究的热点。近年研究表明,ApoA在氧化应激和炎症调节、老化、淀粉样变性、肺纤维化、肿瘤中也有重要作用。本文就ApoA功能的最新研究进展进行综述。Apolipoprotein(Apo)can bind with plasma lipids to form lipoproteins,which is the core components that determine the structure,function,and metabolism of lipoproteins.ApoA is the most important Apo.The mechanism of its action on lipid metabolism and its relationship with cardiovascular disease have always been a hot research topic.In recent years,studies have shown that ApoA plays a crucial role in oxidative stress and inflammation regulation,aging,amyloidosis,pulmonary fibrosis,and tumors.This article provides a review of the latest research progress on the function of ApoA.

关 键 词：载脂蛋白A类 载脂蛋白A-Ⅰ 载脂蛋白A-Ⅱ 载脂蛋白A-Ⅳ 载脂蛋白A-Ⅴ 综述 

分 类 号：R977.6[医药卫生—药品]