口服维生素B_(6)、维生素E预防泌尿系草酸钙结石术后留置双J管附壁结石形成疗效研究  

Study on the efficacy of oral administration of vitamin B_(6) and vitamin E in preventing the formation of indwelling double J tube wall-attached calculus after surgery for calcium oxalate calculus in the urinary system

作　　者：文天斌 陈玉 彭新庆 李秀宁 林玮禹 刘红军 曾春祥 覃建迪 方群鹰 黄海洪 黄广 谢德高 易贤林 唐勇 WEN Tianbin;CHEN Yu;PENG Xinqing;LI Xiuning;LIN Weiyu;LIU Hongjun;ZENG Chunxiang;QIN Jiandi;FANG Qunying;HUANG Haihong;HUANG Guang;XIE Degao;YI Xianlin;TANG Yong(Department of Urology,Wuming Hospital of Guangxi Medical University,Guangxi,Nanning 530199,China)

机构地区：[1]广西医科大学附属武鸣医院泌尿外科,广西南宁530199

出　　处：《中国医药科学》2023年第23期122-125,共4页China Medicine And Pharmacy

基　　金：中华国际科学交流基金会检验检测科技专项基金(Z2020LGX003);广西医疗卫生适宜技术开发与推广应用项目(S2019052);广西医学高层次骨干人才培养“139”培养项目(G201903036)。

摘　　要：目的探讨口服维生素B_(6)、维生素E能否预防泌尿系草酸钙结石术后留置输尿管支架附壁结石形成。方法收集2019年2月至2021年12月广西医科大学附属武鸣医院泌尿外科住院治疗的以草酸钙结石为主的患者临床资料及结石标本。根据纳入及排除标准共筛选出108例结石患者,根据有无用药分为维生素组和空白对照组,其中维生素组44例患者、空白对照组64例患者。分析各组患者结石手术后的双J管置入前后双J管的增重情况、双J管附壁结石形成情况以及患者基线、肌酐、内生肌酐清除率、直接胆红素、间接胆红素等指标。结果口服维生素B_(6)、维生素E后患者取出双J管后附壁结石形成比例为2.27%(1/44),较空白对照组的23.44%(15/64)少,差异有统计学意义(P<0.05)。维生素组患者双J管增重较空白对照组少,差异有统计学意义(P<0.05)。两组患者肌酐、总胆红素、直接胆红素均较术前减低,差异有统计学意义(P<0.05),但组间对比差异均无统计学意义(P>0.05)。结论本研究结果显示口服维生素B_(6)、维生素E可以有效抑制草酸钙结石患者术后置入双J管的双J管附壁结石的形成,二者的联合用药可能是降低草酸钙结石患者术后复发的风险的有效策略。Objective To explore whether oral administration of vitamin B_(6) and vitamin E can prevent the formation of indwelling ureteral stent-attached calculus after surgery for calcium oxalate calculus in the urinary system.Methods Clinical data and calculus specimens of patients with calcium oxalate calculus hospitalized and treated in the Department of Urology of Wuming Hospital of Guangxi Medical University from February 2019 to December 2021 were collected.According to the inclusion and exclusion criteria,a total of 108 patients with calculus were selected and divided into a vitamin group and a blank control group based on the availability of drug use.Among them,44 patients in the vitamin group and 64 patients in the blank control group were included in the study.The weight gain of double J tubes before and after the placement of double J tubes after calculus surgery,the formation of double J tube wall-attached calculus,and patient baseline,creatinine,endogenous creatinine clearance rate,direct bilirubin,indirect bilirubin,and other indicators in the two groups of patients were analyzed.Results After oral administration of vitamin B_(6) and vitamin E,the proportion of patients with wall-attached calculus after removing the double J tube was 2.27%(1/44),lower than 23.44%(15/64)of the blank control group,with statistically significant difference(P<0.05).Moreover,the weight gain of double J tubes of patients in the vitamin group was significantly lower than that of patients in the blank control group,wit statistically significant difference(P<0.05).Creatinine,total bilirubin and direct bilirubin were reduced in both groups compared with the preoperative period,and the difference was statistically significant(P<0.05),but none of the differences were statistically significant in the between-group comparison(P>0.05).Conclusion This study found that oral administration of vitamin B_(6) and vitamin E can effectively inhibit the formation of double J tube wall-attached calculus after placement of double J tubes in patients

关 键 词：泌尿系统 草酸钙结石 维生素B_(6) 维生素E 双J管 

分 类 号：R691.4[医药卫生—泌尿科学]