海口地区妇女妊娠期特异性甲状腺激素参考值范围的建立  

Establishment of reference range of pregnancy-specific thyroid hormone in women in Haikou area

作　　者：罗书[1] 李书明 黄勇[3] 关红琼[1] Luo Shu;Li Shuming;Huang Yong;Guan Hongqiong(Department of Obstetrics,The Second Affliated Hospital of Hainan Medical College,Haikou 570311,China;The Second Clinical College of Hainan Medical College,Haikou 570311,China;Department of Reproductive Medicine,The Second Affliated Hospital of Hainan Medical College,Haikou 570311,China)

机构地区：[1]海南医学院第二附属医院产科,海南海口570311 [2]海南医学院第二临床医学院,海南海口570311 [3]海南医学院第二附属医院生殖医学科,海南海口570311

出　　处：《实用妇科内分泌电子杂志》2023年第25期1-3,62,共4页Electronic Journal of Practical Gynecological Endocrinology

基　　金：海南省卫生计生行业科研项目(编号20A200264);海医二院2020-02。

摘　　要：目的建立海口地区妇女妊娠期特异性甲状腺激素参考值范围,为亚甲减早期判定提供帮助。方法选取500例门诊常规产检妊娠妇女作为观察组,同期体检的212例非妊娠妇女作为对照组。均采集空腹静脉血,离心分离血清,检测血清促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))水平。比较两组检测结果,并且对比美国甲状腺学会(ATA)指南与参考范围对妊娠女性亚甲减诊断的结果。结果观察组患者T_(1)期、T_(2)期的TSH百分比为P2.5th、P50th的水平均低于对照组(P<0.05),T_(3)期P2.5th、P50th、P97.5th的TSH百分比水平均高于对照组(P<0.05)。观察组T_(3)期P2.5th、P50th、P97.5th的FT_(3)、FT_(4)百分比水平均低于对照组(P<0.05)。研究制定的参考值范围同ATA指南判定亚甲减情况比较,差异无统计学意义(P>0.05)。结论建立海口地区妇女妊娠期特异性甲状腺激素参考值范围,能够对妊娠女性进行早期甲状腺相关疾病筛查以及评价,有助于早期干预及改善妊娠结局。Objective To establish the reference value range of pregnation-specific thyroid hormone in women in Haikou area,and to provide help for early determination of subhypothyroidism.Methods 500 pregnant women were selected as the observation group and 212 non-pregnant women were selected as the control group.Fasting venous blood was collected,serum was separated by centrifuge,and serum levels of thyrotropin(TSH),free triodothyronine(FT_(3))and free thyroxine(FT_(4))were detected.The results of the two tests were compared,and the results of the American Thyroid Society(ATA)guidelines and reference ranges for the diagnosis of subthyroidism in pregnant women were compared.Results In the observation group,the TSH percentage of P2.5th at T_(1)and T_(2)was lower than that of the control group(P<0.05),while the TSH percentage of P2.5th,P97.5th at T_(3)was higher than that of the control group(P<0.05).The FT_(3)and FT_(4)percentage levels of P2.5th,P97.5th in T_(3)phase in observation group were lower than those in control group(P<0.05).There was no significant difference between the reference value range established in the study and the ATA guideline in determining subthyroidism(P>0.05).Conclusion Establishing the reference range of pregnancy-specific thyroid hormone for women in Haikou area can screen and evaluate early thyroid related diseases in pregnant women,and help early intervention and improve pregnancy outcome.

关 键 词：妊娠期 特异性甲状腺激素 疾病筛查 

分 类 号：R714.256[医药卫生—妇产科学]