血清S-100B蛋白、可溶性凝集素样氧化低密度脂蛋白受体-1、胶质纤维酸性蛋白检测在新生儿缺血缺氧性脑病病情严重程度中的诊断价值  

Diagnostic value of serum S-100B protein,sLOX-1 and GFAP in severity of neonatal hypoxic-ischemic encephalopathy

作　　者：耿淑霞[1] GENG Shuxia(Department of Neonatology,Xingtai People’s Hospital,Xingtai 054000,China)

机构地区：[1]邢台市人民医院新生儿科,河北邢台054000

出　　处：《陕西医学杂志》2024年第1期118-121,共4页Shaanxi Medical Journal

基　　金：国家自然科学基金资助项目(82173519);河北省邢台市科技计划项目(2023ZC)。

摘　　要：目的:探讨血清S-100B蛋白、可溶性凝集素样氧化低密度脂蛋白受体-1(sLOX-1)、胶质纤维酸性蛋白(GFAP)与新生儿缺血缺氧性脑病(HIE)病情严重程度的关系。方法:选择80例HIE患儿作为观察组,另选择90例健康新生儿作为对照组,收集所有患儿一般资料,并检测两组患儿血清S-100B蛋白、sLOX-1、GFAP水平,分析HIE患儿血清S-100B蛋白、sLOX-1、GFAP与病情严重程度的相关性及预后不良的影响因素。结果:对照组血清S-100B蛋白、sLOX-1、GFAP水平低于观察组(均P<0.05)。重度组血清S-100B蛋白、sLOX-1、GFAP水平高于中度组、轻度组和对照组(均P<0.05)。Pearson相关分析显示,疾病严重程度与HIE患儿血清S-100B蛋白、sLOX-1、GFAP水平呈正相关(均P<0.001)。随访预后良好患儿59例,预后不良21例,经多因素Logistic回归分析显示,产程异常、病情重度、S-100B蛋白、sLOX-1、GFAP为影响HIE患儿预后的危险因素(均P<0.05)。结论:HIE患儿病情严重程度和预后与血清S-100B蛋白、sLOX-1、GFAP水平有关,监测其水平变化有利于临床早期完善干预方案改善预后。Objective:To investigate the relationship between serum S-100B protein,soluble lectin like oxidized low density lipoprotein receptor-1(sLOX-1),glial fibrillary acidic protein(GFAP)and the severity of neonatal hypoxic encephalopathy(HIE).Methods:Eighty children with HIE were selected as the observation group,and 90 healthy newborns were selected as the control group.General data of all children were collected,and serum S-100B protein,sLOX-1 and GFAP levels were detected in the two groups.The correlation of serum S-100B protein,sLOX-1,GFAP with the severity of HIE and the influencing factors of poor prognosis were analyzed.Results:the control group of serum S-100B protein,sLOX-1,GFAP level is lower than the observation group(all P<0.05).Serum levels of S-100B protein,sLOX-1 and GFAP in severe group were higher than those in moderate group,mild group and control group(all P<0.05).Pearson correlation analysis showed that the disease severity was positively correlated with the levels of S-100B protein,sLOX-1 and GFAP in serum of HIE children(all P<0.05).A total of 59 children with good prognosis and 21 with poor prognosis were followed up.Multivariate Logistic regression analysis showed that abnormal labor process,severity of disease,S-100B protein,sLOX-1 and GFAP were the risk factors affecting the prognosis of HIE children(all P<0.05).Conclusion:The severity and prognosis of HIE children are related to the levels of serum S-100B protein,sLOX-1 and GFAP,and monitoring the changes of their levels is conducive to improving the early clinical intervention plan and improving the prognosis.

关 键 词：S-100B蛋白 可溶性凝集素样氧化低密度脂蛋白受体-1 胶质纤维酸性蛋白 新生儿缺血缺氧性脑病 相关性 预后 

分 类 号：R722.1[医药卫生—儿科]