N6-甲基腺苷修饰在呼吸系统疾病中的研究进展  

Progress in studying RNA m6A modification in respiratory diseases

作　　者：韩永康 杜毓锋[2] 钱力[2] 李丹[2] 孙梓越 刘学军[2] HAN Yongkang;DU Yufeng;QIAN Li;LI Dan;SUN Ziyue;LIU Xuejun(Shanxi Medical University,Taiyuan 030012,China)

机构地区：[1]山西医科大学,山西太原030012 [2]山西医科大学第一医院老年病科,山西太原030001

出　　处：《陕西医学杂志》2024年第1期136-139,144,共5页Shaanxi Medical Journal

基　　金：山西省自然科学基金资助面上项目(20210302123248);山西省青年科学研究项目(202203021222373)。

摘　　要：慢性呼吸系统疾病已成为影响我国居民健康的重要因素,给患者、社会带来沉重的经济负担。表观遗传因素在呼吸系统疾病的发生发展中有重要作用,RNA甲基化是重要表观遗传修饰方式之一,其中6-甲基腺嘌呤(m6A)作为一种转录后修饰方式在真核生物中广泛存在。关注m6A修饰在肺部疾病中的功能,对深入理解m6A表观遗传学调控规律,阐明肺部疾病的发病机制,提供药物治疗靶点,指导临床诊治具有重要意义。将对RNA m6A修饰在呼吸系统疾病中的研究进展作一综述。Chronic Respiratory disease have become an important part of the health of Chinese residents,and have a heavy economic burden on patients’families and even the whole society.Epigenetic factors play an important role in the occurrence and development of respiratory diseases,and RNA methylation is one of the important epigenetic modification methods,among which 6-methyladenine(N6-methyladenosine,m6A)is widely present in eukaryotes as a post-transcriptional modification mode.Focusing on the function of m6A modification in lung diseases is of great significance for in-depth understanding of the epigenetic regulation of m6A,elucidating the pathogenesis of lung diseases,providing drug treatment targets,and guiding clinical diagnosis and treatment.This article will review the latest developments in RNA m6A modification in respiratory diseases.

关 键 词：肺部疾病 RNA甲基化 N6-甲基腺苷修饰 甲基化转移酶 去甲基化酶 甲基化阅读蛋白 

分 类 号：R563[医药卫生—呼吸系统]