广西免疫重建不良的人类免疫缺陷病毒感染者发生机会性感染的特点  

Characteristics of opportunistic infections in HIV⁃infected individuals with suboptimal immune reconstruc⁃tion in Guangxi

作　　者：吉磊 李甜甜 吴健林 徐贤丽 张春兰 劳晓洁 梅馨尹 卢扬妮 陈茂伟 JI Lei;LI Tiantian;WU Jianlin;XU Xianli;ZHANG Chunlan;LAO Xiaojie;MEI Xinyin;LU Yangni;CHEN Maowei(Wuming School of Clinical Medicine,Guangxi Medical University,Nanning 530199,China;不详)

机构地区：[1]广西医科大学武鸣临床医学院,南宁530199 [2]贵港市人民医院,广西贵港537199 [3]广西医科大学附属武鸣医院感染科,南宁530199 [4]首都医科大学附属北京地坛医院感染科,北京100015 [5]中国医学科学院肿瘤医院深圳医院,广东深圳518116

出　　处：《实用医学杂志》2023年第23期3082-3086,共5页The Journal of Practical Medicine

基　　金：广西壮族自治区卫生健康委员会西医类别自筹经费科研课题(编号:Z20211281);广西壮族自治区南宁市武鸣区科学技术局基金资助项目(编号:20190402)。

摘　　要：目的探究广西免疫重建不良的人类免疫缺陷病毒(HIV)感染者发生机会性感染的特点,为预防性临床诊疗提供参考。方法收集在广西医科大学附属武鸣医院长期随访的112例经抗逆转录病毒治疗(ART)治疗后免疫重建不良的HIV感染者发生机会性感染的情况及临床信息,并分析基线CD4^(+)T淋巴细胞计数对机会性感染率、机会性感染类型及混合感染率的影响。结果112例免疫重建不良的HIV感染者发生机会性感染率高达42.86%,感染类型以真菌感染居首位。基线CD4^(+)T淋巴细胞计数≤50个/μL患者的机会性感染率显著高于基线CD4^(+)T淋巴细胞计数>50个/μL的患者,而机会性感染类型和混合感染率未见明显差异。结论广西免疫重建不良的HIV感染者发生机会性感染率较高,尤其是基线CD4^(+)T淋巴细胞计数≤50个/μL的患者,感染类型以真菌感染为主。Objective To explore the characteristics of opportunistic infections(OIs)in HIV⁃infected indi⁃viduals with suboptimal immune reconstitution after ART treatment so as to provide a reference for preventing and managing HIV infections.Methods The clinical data including opportunistic infections specifically were acquired from 112 HIV⁃infected individuals with suboptimal immune reconstitution from the outpatient department of Wuming Hospital,Guangxi Medical University.The impact of baseline CD4^(+)T lymphocyte counts on the incidence,type,and mixed infection rates of the opportunistic infections were analyzed.Results The opportunistic infection rate among the 112 HIV⁃infected individuals with suboptimal immune reconstitution was 42.86%,among which fungal infections were the most commonly seen.The opportunistic infection rate of the patients with a baseline of CD4^(+)T lymphocyte counts≤50/μL was significantly higher than that of the patients with a baseline of CD4^(+)T lymphocyte counts>50/μL,and there was no significant difference in the type of opportunistic infections as well as the rate of mixed infections.Conclusion HIV⁃infected people with suboptimal immune reconstitution in Guangxi are susceptible to HIV OIs.Among them,the group with a baseline CD4^(+)T lymphocyte counts≤50/μL has a higher rate of OIs,mainly fungal infections.

关 键 词：人类免疫缺陷病毒 机会性感染 免疫功能重建不良 抗逆转录病毒治疗 

分 类 号：R512.91[医药卫生—内科学]