门冬胰岛素联合甘精胰岛素治疗1型糖尿病患儿对血糖控制、低血糖的影响  

Effect of Insulin Aspartate Combined with Insulin Glargine on Blood Glucose Control and Hypoglycemia in Children with Type I Diabetes

作　　者：王东琦 颜才进[1] 黄宝君[1] WANG Dongqi;YAN Caijin;HUANG Baojun(Department of Pediatrics,Xinglin Branch of the First Affiliated Hospital of Xiamen University,Xiamen,Fujian Prov-ince,361000 China)

机构地区：[1]厦门大学附属第一医院杏林院区儿科,福建厦门361000

出　　处：《糖尿病新世界》2023年第21期66-69,共4页Diabetes New World Magazine

摘　　要：目的分析门冬胰岛素联合甘精胰岛素治疗1型糖尿病患儿对血糖控制、低血糖的影响。方法选取2020年9月—2022年12月厦门大学附属第一医院儿科收治的64例1型糖尿病患儿作为研究对象,以抽签法分为两组,各32例。对照组采用传统治疗方案,观察组采用门冬胰岛素+甘精胰岛素治疗,对比两组患儿的血糖、血脂水平、胰岛素日用量及血糖达标时间、发生低血糖情况、不良反应。结果治疗后观察组血糖、血脂水平均低于对照组,差异有统计学意义(P<0.05);观察组的胰岛素日用量及血糖达标时间均短于对照组,差异有统计学意义(P<0.05);观察组低血糖发生率为3.13%,低于对照组的25.00%,差异有统计学意义(P<0.05)。结论门冬胰岛素+甘精胰岛素能够有利于1型糖尿病患儿更好地控制血糖,且对血脂有一定影响,能够减少在保证效果的同时减少胰岛素用量,促进血糖早日达标,并减少低血糖情况发生,安全性尚可。Objective To analyze the effects of insulin aspartate combined with insulin glargine on blood glucose con-trol and hypoglycemia in children with type I diabetes.Methods 64 patients with type I diabetes who were admitted to the Department of Pediatrics of the First Affiliated Hospital of Xiamen University from September 2020 to December 2022 were selected as study subjects and divided into two groups by drawing lots,with 32 cases in each.The control group was treated with traditional treatment,and the observation group was treated with insulin aspartate+insulin glargine.Blood glucose,blood lipid levels,daily insulin dosage,blood glucose standard time,hypoglycemia and ad-verse reactions were compared between the two groups of children.Results After treatment,the blood glucose and blood lipid levels in the observation group were lower than those in the control group,and the differences were statisti-cally significant(P<0.05).The daily insulin dosage and blood glucose standard time of observation group were shotter than those of control group,and the differences were statistically significant(P<0.05).The incidence of hypoglycemia in the observation group was 3.13%,which was lower than that in the control group by 25.00%,and the difference was statistically significant(P<0.05).Conclusion Insulin aspartate plus insulin glargine can help children with type I dia-betes to better control blood glucose,and has a certain impact on blood lipids.It can reduce the amount of insulin while ensuring the effect,promote blood glucose to reach the standard as soon as possible,and reduce the occurrence of hypoglycemia,and the safety is reasonable.

关 键 词：门冬胰岛素 甘精胰岛素 1型糖尿病 小儿 血糖控制 

分 类 号：R587[医药卫生—内分泌]