罂粟碱治疗早期糖尿病足的临床疗效及对患者炎症反应的影响  

Clinical Efficacy of Papaverine in the Treatment of Early Diabetic Foot and Its Influence on the Inflammatory Response of Patients

作　　者：陈协燊 林雅萍 郑映芳 CHEN Xieshen;LIN Yaping;ZHENG Yingfang(Department of Endocrinology,Chenghai District People's Hospital,Shantou,Guangdong Province,515800 China;Department of Pharmacy,Chenghai District Yanhong Town Hospital,Shantou,Guangdong Province,515800 China)

机构地区：[1]汕头市澄海区人民医院内分泌科,广东汕头515800 [2]汕头市澄海区盐鸿镇卫生院药剂科,广东汕头515800

出　　处：《糖尿病新世界》2023年第21期175-178,共4页Diabetes New World Magazine

摘　　要：目的探讨罂粟碱治疗早期糖尿病足的临床疗效及对患者炎症反应的影响。方法选取2021年6月—2022年12月汕头市澄海区人民医院内分泌科收治的60例早期糖尿病足患者为研究对象,采用随机数表法分为对照组和观察组,各30例。对照组行常规治疗,观察组在对照组基础上加罂粟碱治疗。比较两组早期糖尿病足患者临床疗效和炎性因子水平,包括白细胞介素-6,肿瘤坏死因子-α,成纤维细胞生长因子2。结果观察组总有效率(93.33%)高于对照组(73.33%),差异有统计学意义(P<0.05)。治疗后,观察组的各项炎性因子水平都明显低于对照组,差异有统计学意义(P<0.05)。结论罂粟碱对于早期糖尿病足的治疗效果很好,可提高临床疗效,改善患者炎性反应,促进患者康复。Objective To investigate the clinical efficacy of papaverine in the treatment of early diabetic foot and the effect on the inflammatory response of patients.Methods A total of 60 patients with early diabetic foot admitted to the Endocrinology Department of Chenghai District People's Hospital of Shantou City from June 2021 to December 2022 were selected as the study objects,and were divided into control group and observation group with 30 cases each by random number table method.The control group was treated with routine treatment,and the observation group was treated with papaverine on the basis of the control group.The clinical efficacy and the levels of inflammatory factors,including interleukin-6,tumor necrosis factor-α,fibroblast growth factor 2,were compared between the two groups.Results The total effective rate of the observation group was 93.33%,which was higher than 73.33%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of inflammatory factors in the observation group were significantly lower than those in the control group,and the differences were statistically sig-nificant(P<0.05).Conclusion Papaverine has a good clinical effect on early diabetic foot,which can improve clinical efficacy,improve inflammatory response and promote rehabilitation of patients.

关 键 词：罂粟碱 早期糖尿病足 炎症 

分 类 号：R4[医药卫生—临床医学]