丹参川芎嗪与阿托伐他汀钙联合用药方案治疗急性心肌梗死的效果评价  

Effectiveness Evaluation of Salvia Miltiorrhiza Ligustrazine Combined with Atorvastatin Calcium in the Treatment of Acute Myocardial Infarction

作　　者：白执 BAI Zhi(Department of Internal Medicine,Shenyang 739 Hospital,Shenyang 110034,China)

机构地区：[1]沈阳七三九医院内三科,沈阳110034

出　　处：《中国医药指南》2024年第1期82-84,共3页Guide of China Medicine

摘　　要：目的探讨丹参川芎嗪联合阿托伐他汀钙治疗急性心肌梗死的疗效,为临床医师选择合理用药方案提供参考。方法选取2019年1月1日至2019年12月31日沈阳七三九医院诊治的急性心肌梗死患者52例作为研究对象,依据随机数字表法,将研究样本均分为两组,分别为对照组与观察组,每组26例。在基础治疗的前提下,对照组采用阿托伐他汀钙,观察组则同时应用丹参川芎嗪与阿托伐他汀钙。对比分析两组患者治疗效果以及心功能指标的改变。结果观察组的临床疗效(92.31%)优于对照组(69.23%)(P=0.035)。治疗后,观察组的心功能指标,包括每搏输出量、中心静脉压及左室射血分数,均较治疗前明显改善(P<0.05),且三项指标均优于对照组(P<0.05)。结论丹参川芎嗪与阿托伐他汀钙联合用药方案治疗急性心肌梗死的效果明显,能改善患者心功能。Objective To explore the clinical effect of salvia miltiorrhiza ligustrazine combined with atorvastatin calcium in the treatment of acute myocardial infarction,so as to provide reference for clinicians to choose rational drug use regimen.Methods During from January 1,2019 to December 31,2019,a total of 52 patients with acute myocardial infarction in Shenyang 739 hospital were selected as the research objects.According to the random number table method,the study samples were evenly divided into two groups,namely the control group and the observation group,each containing 26 subjects.Under the premise of basic treatment,the control group received atorvastatin calcium,while the observation group received both salvia miltiorrhiza,ligustrazine,and atorvastatin calcium.Subsequent comparative analysis of treatment outcomes and changes in cardiac function indicators between the two groups of patients.Results The clinical efficacy of the observation group(92.31%)was significantly better than that of the control group(69.23%),and this difference was statistically significant(P=0.035).After treatment,the cardiac function indicators of the observation group,including stroke output(SV),central venous pressure(CVP),and left ventricular ejection fraction(LVEF),were significantly improved compared to before treatment,and this change was also statistically significant(P<0.05).In addition,these three indicators were all better than the control group,and this difference was also statistically significant(P<0.05).Conclusions The combination therapy of salvia miltiorrhiza ligustrazine and atorvastatin calcium has a significant clinical effect in the treatment of acute myocardial infarction,and can improve various indicators of cardiac function in patients.

关 键 词：急性心肌梗死 丹参川芎嗪 阿托伐他汀钙 联合用药 临床合理用药 效果 

分 类 号：R542.22[医药卫生—心血管疾病]