有限元建模和分析在膝骨关节炎退变中的研究进展  

Research progress on finite element modeling and analysis of knee osteoarthritis degeneration

作　　者：解敏坤[1] 李曈曈 魏学磊[2] XIE Minkun;LI Tongtong;WEI Xuelei(Department of Preventive Health Care,Tianjin Hospital,Tianjin University,Tianjin 300211,China;Department of Trauma Upper Extremity,Tianjin Hospital,Tianjin University,Tianjin 300211,China)

机构地区：[1]天津市天津医院(天津大学天津医院)预防科,天津300211 [2]天津市天津医院(天津大学天津医院)骨科上肢一科,天津300211

出　　处：《中国体视学与图像分析》2023年第3期279-284,共6页Chinese Journal of Stereology and Image Analysis

基　　金：天津市科技局课题(21KPHDRC00160);天津市应用基础研究多元投入基金项目(21JCQNJC01360)。

摘　　要：骨关节炎(osteoarthritis, OA)是中老年人最常见的膝关节疾病,其发生是机械和生物性因素相互作用的结果,膝关节是一个复杂的机械系统,膝OA过程中生物力学变化对于预测疾病进展具有重要作用。有限元(finite element, FE)建模和分析技术是一种有效的工具,可以帮助研究人员预测和评估膝OA的发展和进展。本综述概述模拟膝关节不同解剖结构退化FE模型(包括关节软骨、软骨下骨、软骨退变和软骨下骨重塑耦合、半月板肌肉骨骼及前交叉韧带重建FE模型)所涉及的挑战和治疗进展,并对所面临问题进行分析和讨论。Osteoarthritis(OA)is the most prevalent knee joint disease in middle-aged and elderly persons.It occurs as the result of the interaction of mechanical and biological elements.The knee joint is an intricate mechanical system.Examining the biomechanical changes of the knee OA are critical in predicting disease progression.Finite element(FE)modeling and analysis techniques are an effective tool for researchers to predict and evaluate the development and progression of knee OA.This paper summarizes and discusses the challenges and therapeutic progress in generating FE models simulating distinct anatomical structures of the knee articular and their degeneration,including articular cartilage,subchondral bone,combined subchondral bone and cartilage degeneration,meniscal musculoskeletal,and anterior cruciate ligament.The related problem is analyzed and discussed.

关 键 词：骨关节炎 生物力学 有限元建模 膝关节 

分 类 号：R687.4[医药卫生—骨科学] N3[医药卫生—外科学]