中药颗粒剂外敷对0~4月龄小婴儿新型冠状病毒感染退热效果的临床观察  

Clinical observation on antipyretic effect of external external application of TCM granules on babies aged 0-4 months infected with COVID-19

作　　者：王桂玲[1] 杨江[2] 王媛媛[1] 耿雨作 WANG Guiling;YANG Jiang;WANG Yuanyuan;GENG Yuzuo(Pediatric Department of Suqian TCM Hospital,Suqian 223800,China)

机构地区：[1]宿迁市中医院儿科,江苏宿迁223800 [2]江苏省中医院儿科,南京210000

出　　处：《中国中西医结合儿科学》2023年第6期514-517,共4页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：江苏省中医药科技计划项目(MS-20121093);宿迁市重大科技研发社会发展项目(S202106)。

摘　　要：目的观察自拟中药机器颗粒剂外敷对0~4月龄小婴儿新型冠状病毒感染发热退热的效果。方法选取2022年11月至2023年1月宿迁市中医院儿科救治的0~4月龄新型冠状病毒感染发热中度以上患儿132例,随机分为观察组68例和对照组64例。对照组≥38℃采用医用降温贴贴敷于额头,观察组采用自拟中药颗粒剂外敷神阙穴,3 d后统计退热效果。若合并细菌感染、热性惊厥等者,予抗感染、补液、止惊等对症处理。比较两组患儿治疗后的退热效果、退热起效时间。结果观察组总有效率为92.65%(63/68),明显高于对照组76.56%(49/64),差异有统计学意义(P<0.05)。观察组治疗6 h、24 h、48 h、72 h后退热幅度均较对照组显著,差异有统计学意义(P<0.05)。观察组的退热起效时间节点较对照组明显前移,两组比较差异有统计学意义(P<0.05)。结论自拟中药机器颗粒剂外敷对0~4月龄小婴儿新型冠状病毒感染发热退热效果显著,能明显缩短小婴儿中度以上发热的持续时间,使退热起效时间点明显前移,且未见不良反应,值得临床推广应用。Objective To observe the antipyretic effect of external application of self-made TCM granules on babies aged 0-4 months infected with COVID-19.Methods Totally 132 babies aged 0-4 months with moderate fevel or above due to COVID-19 infection were chosen,who were treated in Suqian TCM Hospital from Nov.2022 to Jan.2023,and they were divided into two group:68 in observation group and 64 in control group.In control group,the babies with body temperature≥38℃were given medical antipyretic patches on their forehead;in observation group,the babies received external application of self-made TCM granules on Shenque acupoint;after 3 days of treatment,the antipyretic effect was recorded.For those with bacterial infection,febrile convulsions,etc.,the symptomatic treatment of anti-infection,fluid supplimentation and stopping convulsions was performed.Compare the antipyretic effect and the starting time of antipyretic effect after treatment between the two groups.Results The total effect rate of observation group was 92.65%(63/68),significantly higher than that of control group(76.56%,49/64),and the differences were statistically significant(P<0.05).The dorp in temperature of observation group at 6h,24h,48h and 72h after treatment was greater than that of control group(P<0.05).The starting time of antipyretic effect in observation group was prior to that in control group,and there was statistical difference between the two groups(P<0.05).Conclusion The external application of self-made TCM granules has significant antipyretic effect on the babies aged 0-4 month infected with COVID-19;it can greatly shorten the duration of moderate fever or above and fasten the starting of antipyretic effect,and there is no adverse reaction,so it is worthy of clinical application.

关 键 词：新型冠状病毒感染 发热 自拟中药颗粒剂外敷 0~4月龄婴幼儿 

分 类 号：R725.6[医药卫生—儿科]