蚕丝基小口径人工血管研究进展  

Research progress on silk-based small-caliber artificial blood vessels

作　　者：曾姚 吕金凤[1] 王介平[1] 刘彬[2] 周婵[1] ZENG Yao;L Jinfeng;WANG Jieping;LIU Bin;ZHOU Chan(Technology Institute of Silk and Mulberry,Chongqing Academy of Animal Sciences,Chongqing 402460,China;School of Life Sciences,Southwest University,Chongqing 400715,China)

机构地区：[1]重庆市畜牧科学院蚕业研究所,重庆402460 [2]西南大学生命科学学院,重庆400715

出　　处：《丝绸》2024年第1期38-45,共8页Journal of Silk

基　　金：重庆市科研院所绩效激励引导专项项目(22531J,22529J,cstc2022jxjl0259);重庆荣昌农牧高新技术产业研发专项项目(22541C-22);重庆市现代山地特色效益农业(蚕桑)技术体系多元化发展研究室项目(18304)。

摘　　要：心血管疾病居全球死亡率首位,其中冠状动脉和周边堵塞性血管疾病威胁巨大。为了降低该疾病对人类生命的严重威胁,小口径人工血管移植术(搭桥)是较为普遍的治疗手段,但目前常用的制备方法和材料存在长期通畅率低、易形成血栓和难以在体内促进血管内皮化等问题。桑蚕丝因具备良好的力学性能、生物相容性及可控的生物降解性而被广泛用于小口径人工血管。本文综述了蚕丝基小口径人工血管在动物体内的应用,总结了以蚕丝基为材料制备小口径血管的优势,分析了存在的缺陷和改进方向,以期为蚕丝基小口径人工血管的研究发展提供参考。Cardiovascular diseases(CVDs)are a group of diseases with high prevalence,disability and mortality rates,and are the number one killer of human health,with coronary and peripheral occlusive vascular diseases posing a great threat.To reduce the threat of CVDs to human life,small-caliber artificial blood vessel transplantation is a relatively common treatment.The materials widely used for the preparation of artificial blood vessels include polyester,expanded polytetrafluoroethylene,polyurethane and silk,etc.The former three are widely used in large vessel replacement surgery,but their use in small vessels is prone to thrombus formation,which clogs the artificial blood vessels and ultimately leads to the death of the organism.Silk has good biocompatibility,mechanical properties,degradability and promotion of cell adhesion,which has become a research hotspot for the preparation of small-caliber artificial blood vessels in recent years.To comprehensively understand the application status and performance advantages of silk small-caliber artificial blood vessels and accelerate the research and transformation of small-caliber blood vessels,this paper analyzed the advantages and problems of using silk as raw material to prepare small-caliber blood vessels from the aspects of preparation method,biocompatibility,anti-thrombotic ability and promoting vascular endothelialization,and put forward the possible development direction in the future.The results of most of the studies show that small-caliber artificial blood vessels prepared with silk as raw material exhibit good repair and long-term patency in animals.Silk can be prepared by gel spinning,weaving,knitting,electrostatic spinning,3D printing,decellularization,freeze drying,etc.These methods have both advantages and defects.For instance,freeze drying is easy to mold but the mechanical properties of the artificial blood vessels are weak,the method of gel spinning can produce a uniform and loose network structure but is poor in mechanical properties,the artificial blood v

关 键 词：蚕丝 丝素蛋白 心血管疾病 小口径人工血管 抗血栓 内皮化 

分 类 号：TS101.4[轻工技术与工程—纺织工程]