基于真实世界数据的温散酊透皮给药治疗肺结节的疗效评价  

Evaluation of the efficacy of transdermal administration of Wensan Tincture in the treatment of pulmonary nodules based on real-world data

作　　者：刘晓红 张金枝 张皓翔 王梅林 刘俨熠 夏潇 李光熙[1] LIU Xiaohong;ZHANG Jinzhi;ZHANG Haoxiang;WANG Meilin;LIU Yanyi;XIA Xiao;LI Guangxi(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Beijing University of Chinese Medicine,Bejing 100029,China)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学,北京100029

出　　处：《长春中医药大学学报》2023年第12期1364-1369,共6页Journal of Changchun University of Chinese Medicine

基　　金：国家自然科学基金(82074262)。

摘　　要：目的基于中医真实世界数据评价温散酊透皮给药治疗肺结节的疗效。方法回顾性分析纳入1315例肺结节患者,分为温散酊透皮给药治疗暴露组342例,非暴露组973例,记录研究时间窗内肺结节大小变化及进展情况。运用倾向性评分法按照1:1遗传匹配法进行匹配,以均衡2组间混杂因素,比较暴露组和非暴露组肺结节进展差异,并观察暴露组内不同累计暴露值肺结节进展情况。结果经倾向性评分匹配后暴露组、非暴露组各305例,匹配后暴露组和非暴露组肺结节增长率差异有统计学意义(P<0.001),暴露组内,随着累计暴露值增大,肺结节进展发生率呈下降趋势。结论温散酊透皮给药治疗能降低肺结节的增长率,有效抑制肺结节生长,延缓肺结节进展。Objective To evaluate the effect of transdermal administration of Wensan Tincture in the treatment of pulmonary nodules based on real-world data of traditional Chinese medicine.Methods The data of 1315 patients with pulmonary nodules enrolled were retrospectivelty analyzed.The patients were divided into the exposed group(n=342)treated with transdermal administration of Wensan Tincture and the non-exposed group(n=973).The changes and progression of pulmonary nodules within the study time window were recorded.Using propensity score matching method,match was performed according to the 1:1 genetic matching method to balance confounding factors between the two groups.The differences in pulmonary nodule progression between the exposed group and the non-exposed group were compared,and the pulmonary nodule progression between different cumulative exposure values in the exposed group was observed.Results There were 305 cases in the exposed group and 305 cases in the non-exposed group after propensity score matching.There was statistically significant difference in the growth rate of pulmonary nodules between the exposed group and the non-exposed group after matching(P<0.001).In the exposed group,the incidence of pulmonary nodule progression decreased with the increase of cumulative exposure values.Conclusion Transdermal administration of Wensan Tincture can reduce the growth rate of pulmonary nodules,effectively inhibit the growth of pulmonary nodules and delay the progression of pulmonary nodules.

关 键 词：肺结节 温散酊 透皮给药 真实世界研究 疗效评价 

分 类 号：R244.9[医药卫生—针灸推拿学]