Silica-based nanoarchitecture for an optimal combination of photothermal and chemodynamic therapy functions of Cu2–xS cores with red emitting carbon dots  

作　　者：Alexey Stepanov Svetlana Fedorenko Kirill Kholin Irek Nizameev Alexey Dovzhenko Rustem Zairov Tatiana Gerasimova Alexandra Voloshina Anna Lyubina Guzel Sibgatullina Dmitry Samigullin Asiya Mustafina 

机构地区：[1]Arbuzov Institute of Organic and Physical Chemistry,FRC Kazan Scientific Center of RAS,Kazan 420088,Russia [2]Department of Physics,Kazan National Research Technological University,Kazan 420015,Russia [3]Department of Nanotechnology in Electronics,Kazan National Research Technical University named after A.N.Tupolev-KAI,Kazan 420111,Russia [4]Kazan(Volga region)Federal University,Kazan 420008,Russia [5]Kazan Institute of Biochemistry and Biophysics,FRC Kazan Scientific Center of RAS,Kazan 420111,Russia

出　　处：《Frontiers of Chemical Science and Engineering》2023年第12期2144-2155,共12页化学科学与工程前沿（英文版）

基　　金：funded by RFBR and CNR, project number 20-53-7802.

摘　　要：This study introduces multifunctional silica nanoparticles that exhibit both high photothermal and chemodynamic therapeutic activities,in addition to luminescence.The activity of the silica nanoparticles is derived from their plasmonic properties,which are a result of infusing the silica nanoparticles with multiple Cu2-xS cores.This infusion process is facilitated by a recoating of the silica nanoparticles with a cationic surfactant.The key factors that enable the internal incorporation of the Cu2-xS cores and the external deposition of red-emitting carbon dots are identified.The Cu2-xS cores within the silica nanoparticles exhibit both self-boosting generation of reactive oxygen species and high photothermal conversion efficacy,which are essential for photothermal and chemodynamic activities.The silica nanoparticles’small size(no more than 70 nm)and high colloidal stability are prerequisites for their cell internalization.The internalization of the red-emitting silica nanoparticles within cells is visualized using fluorescence microscopy techniques.The chemodynamic activity of the silica nanoparticles is associated with their dark cytotoxicity,and the mechanisms of cell death are evaluated using an apoptotic assay.The photothermal activity of the silica nanoparticles is demonstrated by significant cell death under near-infrared(1064 nm)irradiation.

关 键 词：copper sulfide nanoparticles chemodynamic therapy photothermal therapy carbon dots silica nanoparticles 

分 类 号：O64[理学—物理化学]