Electrochemical Chiral Recognizing Tryptophan Enantiomers Based on Chiral Metal-Organic Framework D-MOF  

作　　者：HOU Huipeng TANG Shanshan WANG Wei LIU Miao LIANG Axin XIE Bingteng YI Yue LUO Aiqin 

机构地区：[1]Key Laboratory of Molecular Medicine and Biotherapy,School of Life Science,Beijing Institute of Technology,Beijing 100081,P.R.China

出　　处：《Chemical Research in Chinese Universities》2023年第6期976-984,共9页高等学校化学研究（英文版）

基　　金：supported by the National Key R&D Program of China(No.2019YFA0904104).

摘　　要：In this work,an electrochemical chiral sensor of a nanowire-like chiral metal-organic framework/multiwalled carbon nanotube-chitosan/glassy carbon electrode(D-MOF/MWCNTs-CS/GCE)was proposed for the enantiorecognition of L/D-tryptophan(L/D-Trp).The asymmetrical spatial structure of D-MOF provides the feasibility for the enantiorecognition of Trp enantiomers.Moreover,differential pulse voltammetry(DPV)was carried out to be the detection method and the DPV peak potential difference(ΔEp)between L-Trp and D-Trp was referred as the index of the enantiorecognition performance.Several parameters,such as mass ratios and drop-coated volume of MWCNTs-CS,drop-coated volume and concentration of D-MOF,pH and detection temperature of D-MOF/MWCNTs-CS/GCE were optimized for the largestΔEp value.And the molecular dynamics(MD)simulation was used to elucidate the enantiorecognition mechanism.Furthermore,the proportions of D-Trp(D-Trp%)in Trp mixtures were detected in a good linear relationship with the DPV peak potentials(Ep),and the proposed electrochemical chiral sensor exhibited good reproducibility,stability and enantiorecognition ability.Additionally,the proposed electrochemical chiral sensor(D-MOF/MWCNTs-CS/GCE)has a good application prospect in the fields of biomedicine,clinical diagnosis,chemical production,pharmaceuticals safety and so on.

关 键 词：Electrochemical chiral sensor Chiral metal-organic framework Multiwalled carbon nanotube-chitosan(MWCNTs-CS) D-MOF Tryptophan(Trp) Potential difference(ΔEp) 

分 类 号：O62[理学—有机化学]