光动力联合抗真菌药物辅以综合护理干预在治疗脓癣中的效果评价  

Evaluation of the effect of photodynamic therapy combined with antifungal drugs and comprehensive nursing intervention in the treatment of kerion

作　　者：陈小丽 梁愉笳 陈善丹 郑文爱 吴伟伟 CHEN Xiaoli;LIANG Yujia;CHEN Shandan;ZHENG Wenai;WU Weiwei(Department of Plastic and Dermatologic Surgery,the Fifth People's Hospital of Hainan Province,Haikou,Hainan 570102,China;Department of Clinical Laboratory,the Fifth People's Hospital of Hainan Province,Haikou,Hainan 570102,China)

机构地区：[1]海南省第五人民医院整形与皮肤外科,海南海口570100 [2]海南省第五人民医院检验科,海南海口570100

出　　处：《中国热带医学》2023年第11期1228-1230,1236,共4页China Tropical Medicine

基　　金：海南医学临床中心建设项目(No.琼卫医函[2021]276)。

摘　　要：目的 探讨5-氨基酮戊酸(5-aminolevulinic acid, ALA)光动力学疗法(photodynamic therapy, PDT)联合抗真菌药物辅以综合护理干预治疗难治性脓癣的疗效和安全性。方法 针对2019-2022年就诊于海南省第五人民医院的6例难治性脓癣患者进行5-氨基酮戊酸光动力学疗法联合抗真菌药物治疗。将浓度20%的5-氨基酮戊酸溶液均匀滴在棉片上,避光封包3 h后,使用(633±10)nm LED红光照射20~30 min qw,3次为1个疗程。治疗前给予清创、火针预处理,在治疗期间给予及时、针对性的心理护理及健康宣教,缓解患者的负面心理。治疗后6个月内对患者进行随访复查,评估临床疗效、安全性及患者满意度情况。结果 6例患儿接受规范ALA-PDT联合抗真菌药物治疗,辅以综合护理干预,患儿治愈率达100%,均未见病情复发或萎缩性瘢痕。患者及家属满意度100%。结论 ALA-PDT联合抗真菌药物临床效果明显,辅以综合护理干预,有助于缓解患者紧张情绪,可提高脓癣的治疗效果及患者对治疗的依从性,进一步提高患者满意度。Objective To explore the efficacy and safety of photodynamic therapy(PDT)using 5-aminolevulinic acid(ALA)combined with antifungal drugs combined and comprehensive nursing intervention in the treatment of refractory kerion.Methods From January 2019 to December 2022,6 cases of refractory kerion who were treated at the Fifth People's Hospital of Hainan Province with photodynamic therapy(PDT)using 5-aminolevulinic acid(ALA)combined with antifungal drugs.A solution with 20%concentration of ALA solution was uniformly dropped on the cotton sheet,shielded from light for 3 h,and irradiated with(633±10)nm LED red light for 20-30 min.The treatment was performed once a week,with one treatment course consisting of three sessions.Prior to treatment,debridement and fire needles pre-treatment were performed.Provide timely and targeted psychological care during treatment to alleviate psychological negative disorders and health education.Follow-up examinations were conducted 6 months after the treatment to evaluate clinical efficacy,safety and patient satisfaction.Results Six children received standard ALA-PDT combined with antifungal drugs,supplemented by comprehensive nursing intervention.The cure rate of children reached 100%,and no disease relapse or atrophic scar was found.The satisfaction rate of patients and their families was 100%.Conclusions PDT combined with antifungal drugs has obvious clinical efficacy in the treatment of kerion,especially when combined with comprehensive nursing intervention.This approach can help to relieve patients'anxiety,improve treatment outcomes,enhances patient compliance,and further improve patients'satisfaction.

关 键 词：脓癣 光动力疗法 抗真菌药物 护理干预 效果评价 

分 类 号：R756[医药卫生—皮肤病学与性病学]