痰中性粒细胞弹性蛋白酶活性在老年支气管扩张症急性加重期患者疗效评估中的价值  

The value of sputum neutrophil elastase activity in the evaluation of therapeutic effect in elderly patients with acute exacerbation of bronchiectasis

作　　者：丁薇[1] 徐瑾 王再远 王乃玲[2] Ding Wei;Xu Jin;Wang Zaiyuan;Wang Nailing(Department of Geriatrics Medicine,Punan Hospital,Pudong New District,Shanghai,200125,P.R.China;Department of Academic Research and Teaching,Punan Hospital,Pudong New District,Shanghai,200125,P.R.China)

机构地区：[1]上海市浦东新区浦南医院老年医学科,上海200125 [2]上海市浦东新区浦南医院科研教学部,上海200125

出　　处：《老年医学与保健》2023年第6期1200-1202,共3页Geriatrics & Health Care

基　　金：上海市浦东新区科技发展基金项目(PKJ2021-Y90)。

摘　　要：目的比较老年支气管扩张症急性加重期住院患者治疗前后痰中性粒细胞弹性蛋白酶活性,以评估患者的临床疗效,旨在为疗效评估提供方法。方法选取2021年12月—2022年10月在上海市浦东新区浦南医院因支气管扩张症急性加重住院的患者80例,均予以抗感染、化痰等治疗14 d,比较用药前、用药14 d后血白细胞计数(WBC)、中性粒细胞计数(N)、C反应蛋白(CRP)水平、降钙素原(PCT)水平、痰中性粒细胞弹性蛋白酶(neutrophil elastase,NE)活性等差异,以及痰NE活性与上述指标值的相关性。结果患者治疗前后上述各项炎症指标值均有差异,治疗后均较治疗前下降(P<0.05);痰NE活性治疗前后差值与N、CRP、PCT水平治疗前后差值呈正相关性,与WBC差值无相关性。结论痰NE活性有望作为气道炎症标志物用来评估老年支气管扩张症急性加重期患者的治疗效果,具有一定的临床应用价值。Objective To compare the activity of sputum neutrophil elastase(NE)of hospitalized elderly patients with acute exacerbation of bronchiectasis before and after treatment,in order to evaluate the clinical efficacy of patients and provide a method for efficacy evaluation.Methods A total of 80 patients with acute exacerbation of bronchiectasis who were hospitalized in Punan Hospital in Pudong New District from December 2021 to October 2022 were selected.All patients were treated with anti-infection,expectorant and other treatments for 14 days.The differences in blood white blood cell count(WBC),neutrophil count(N),C-reactive protein(CRP)level,procalcitonin(PCT)level,sputum NE activity were compared before and 14 days after treatment.The correlation between sputum NE activity and above indexes was analyzed.Results The values of the above inflammatory indexes were different before and after treatment,and all of them were lower after treatment than before treatment(P<0.05).The difference of sputum NE activity before and after treatment was positively correlated with the differences of the levels of N,CRP and PCT before and after treatment,but not with the difference of WBC.Conclusion Sputum NE activity is expected to be used as an index of airway inflammation to evaluate the therapeutic effect of elderly patients with acute exacerbation of bronchiectasis,and has certain clinical application value.

关 键 词：老年 支气管扩张症 急性加重期 痰中性粒细胞弹性酶 疗效 

分 类 号：R56[医药卫生—呼吸系统]