抗革兰氏阴性菌抗菌肽在畜牧业应用研究进展  

Recent research progress on antibacterial peptides against gram-negative bacteria

作　　者：喻家晓 张明辉 高学军 YU Jiaxiao;ZHANG Minghui;GAO Xuejun(College of Animal Science,Yangtze University,Jingzhou,Hubei 434023,PRC)

机构地区：[1]长江大学动物科学学院,湖北荆州4340233

出　　处：《湖南畜牧兽医》2023年第6期48-52,共5页Hunan Journal of Animal Science & Veterinary Medicine

基　　金：长江大学动物科学学院-武汉大北农农牧发展有限公司联合培养研究生项目(2022)。

摘　　要：革兰氏阴性菌是一类常见的病原微生物,引起腹泻、尿路感染、呼吸道感染、败血症等疾病,给畜牧业带来重大的经济损失。抗菌肽具有广谱抗菌活性、对革兰氏阴性菌具有抑制和杀灭作用,且不易产生耐药性。抗菌肽正逐渐成为新一代抗革兰氏阴性菌药物。文章综述了近年来抗革兰氏阴性菌抗菌肽的研究进展,包括其分类、结构、抗菌机制、在畜牧业的应用等,为其应用于畜牧业抗腹泻等疾病提供基础数据参考。Gram-negative bacteria are a common class of pathogenic microorganisms,which cause diseases such as diarrhea,urinary tract infections,respiratory infections,and sepsis,bringing significant economic losses to animal husbandry.Antimicrobial peptides have broad-spectrum antibacterial activity,inhibit and kill Gram-negative bacteria,and are not easy to develop drug resistance.Therefore,antimicrobial peptides are gradually becoming a new generation of anti-gram-negative drugs.This article reviews the recent research progress on antibacterial peptides against gram-negative bacteria,including the classification,structure,and antibacterial mechanism of antimicrobial peptides.This review would provide basic data reference for their application in animal husbandry to combat diseases such as diarrhea.

关 键 词：革兰氏阴性菌 抗菌肽 畜牧业 研究进展 

分 类 号：S816.7[农业科学—饲料科学]