拮抗剂方案注射HCG后不同授精时间对IVF助孕结局影响  

The Effect of Different Insemination Times After Injection of Hcg With Antagonist Regimen on Ivf Assisted Pregnancy Outcomes

作　　者：杨广铭 梁光林[1] 李结贞 李土珍[1] 赵善飞 Yang Guangming;Liang Guanglin;Li Jiezhen;Li Tuzhen;Zhao Shanfei(Reproductive Medicine Center of Maoming People's Hospital,Maoming,Guangdong Province,525000 China;Pediatrics Department of Maoming People's Hospital,Maoming,Guangdong Province,525000 China)

机构地区：[1]茂名市人民医院生殖医学中心,广东茂名525000 [2]茂名市人民医院儿科,广东茂名525000

出　　处：《系统医学》2023年第20期33-36,共4页Systems Medicine

基　　金：茂名市科技计划项目(2021328)。

摘　　要：目的探讨拮抗剂方案注射人绒毛膜促性腺激素(human choriogonadotropin,HCG)后不同授精时间对体外受精(in vitro fertilization,IVF)助孕结局影响。方法回顾性分析2021年3月—2023年3月在茂名市人民医院生殖中心接受体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)治疗,并采取拮抗剂方案的161例COS患者的临床资料,按照注射HCG后不同授精时间分为4组,其中A组(n=26):注射HCG后的38~39 h(含39 h)授精;B组(n=77):注射HCG后的39~40 h(含40 h)授精;C组(n=46):注射HCG后的40~41 h(含41 h)授精;D组(n=12):注射HCG后的41~42 h(含42 h)授精。比较4组的临床结局。结果D组的优质胚胎率为44.00%高于另外3组,差异有统计学意义(χ^(2)=7.125,P<0.05)。4组的临床妊娠率以及每移植周期活产率对比,差异无统计学意义(P>0.05),但是D组的胚胎着床率和早期流产率均高于另外3组,差异有统计学意义(P<0.05)。结论结果发现,时间在38~42 h内的IVF-ET的临床结局并不会受到拮抗剂方案HCG注射后的不同授精时间影响,但如果在这个时间范围内,将授精时间在一定程度上延迟时,会进一步将患者优质胚胎率增加。Objective To explore the effect of different insemination times after injection of HCG with antagonist regimens on the outcome of IVF assisted pregnancy.Methods A retrospective analysis the chinical data of 161 COS patients who received IVF-ET treatment at the Reproductive Center of Maoming People's Hospital from March 2021 to March 2023 and adopted an antagonist regimen.They were divided into four groups according to different insemination times after HCG injection.Group A(n=26):insemination from 38-39-hour(including 39-hour)after HCG injection;group B(n=77):insemination at 39-40-hour(including 40-hour)after HCG injection;group C(n=46):insemination after injection of HCG for 40-41-hour(including 41-hour);group D(n=12):Intrauterine insemination 41~42-hour(including 42-hour)after HCG injection.Compared the clinical outcomes of four groups.Results The high quality embryo rate of group D 44.00%,which was higher that of anther three groups,and the difference was statistically significant(χ^(2)=7.125,P<0.05).There was no statistically significant difference in embryo clinical pregnancy rate and live birth rate per transfer cycle among the groups,(P>0.05),but the embryo implantatien rate and early miscarriage rate in Group D were better,than those in another three groups,and the differences were statistically significant(P<0.05).Conclusion Within a certain time range(38-42-hour),different insemination times after HCG injection with antagonist regimens do not affect the clinical outcomes of IVF-ET.However,appropriately delaying the timing of fertilization within this time range can effectively increase high-quality embryo rate.

关 键 词：拮抗剂方案 注射人绒毛膜促性腺激素后 不同授精时间 体外受精助孕结局 

分 类 号：R714[医药卫生—妇产科学]