二甲双胍、达格列净结合强化胰岛素治疗新诊断2型糖尿病的临床效果分析  

Clinical Effect of Metformin,Dapagliflozin Combined with Intensive Insu⁃lin in the Treatment of Newly Diagnosed Type 2 Diabetes Mellitus

作　　者：罗银凤 冯志涛 汪蓓蓓 LUO Yinfeng;FENG Zhitao;WANG Beibei(Department of General Medicine,Foshan Fifth People's Hospital,Foshan,Guangdong Province,528000 China;Department of Cardiovascular Medicine,Foshan Fifth People's Hospital,Foshan,Guangdong Province,528000 China)

机构地区：[1]佛山市第五人民医院综合内科,广东佛山528000 [2]佛山市第五人民医院心血管内科,广东佛山528000

出　　处：《中外医疗》2023年第30期110-112,116,共4页China & Foreign Medical Treatment

摘　　要：目的分析二甲双胍、达格列净结合强化胰岛素治疗新诊断2型糖尿病的临床效果。方法随机选取2021年7月—2023年7月佛山市第五人民医院收治的100例新诊断2型糖尿病患者,按照随机抽签法分为两组,每组50例,以二甲双胍+强化胰岛素为对照组,二甲双胍+达格列净+强化胰岛素治疗为观察组,比较两组患者疗效。结果治疗后,两组患者空腹血糖、餐后2 h血糖及糖化血红蛋白均降低,且观察组空腹血糖、餐后2 h血糖及糖化血红蛋白为(6.56±1.31)mmol/L、(10.23±1.32)mmol/L、(7.02±0.23)%,均低于对照组,差异有统计学意义(t=2.718、7.573、10.538,P<0.05);治疗后,两组患者胰岛素β细胞功能指标明显改善,且观察组优于对照组,差异有统计学意义(P<0.05);观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论二甲双胍+强化胰岛素治疗新诊断2型糖尿病效果好,而联合达格列净,可以更为显著改善其血糖及胰岛素功能,减少临床并发症,值得使用。Objective To analyze the clinical effect of metformin,dapagliflozin combined with intensive insulin in the treatment of newly diagnosed type 2 diabetes.Methods A total of 100 patients with newly diagnosed type 2 diabetes admitted to Foshan Fifth People's Hospital from July 2021 to July 2023 were randomly selected and divided into two groups according to random drawing method,with 50 cases in each group.Metformin+intensive insulin was used as control group,metformin+dapagliflozin+intensive insulin was used as observation group.The efficacy of the two groups was compared.Results After treatment,fasting blood glucose,2 hours postprandial blood glucose and glycated hemoglobin decreased in both groups were decreased,and the fasting blood glucose,2 hours postprandial blood glu⁃cose and glycated hemoglobin in the observation group were(6.56±1.31)mmol/L,(10.23±1.32)mmol/L and(7.02±0.23)%,which were lower than those in the control group,the differences were statistically significant(t=2.718,7.573,10.538,P<0.05).After treatment,the function indexes of insulin-βcells in the two groups were significantly improved,and the observation group was better than that in the control group,the difference was statistically signifi⁃cant(P<0.05).The incidence of complications in observation group was lower than that of control group,the difference was statistically significant(P<0.05).Conclusion Metformin plus intensive insulin has a good effect on the treatment of newly diagnosed type 2 diabetes,while the combination of dapagliflozin can significantly improve blood glucose and insulin function,reduce clinical complications,and is worthy of use.

关 键 词：二甲双胍 达格列净 强化胰岛素 新诊断2型糖尿病 血糖 胰岛素功能 并发症 

分 类 号：R587[医药卫生—内分泌]