血清胸苷激酶1与SCC-Ag水平与宫颈鳞癌治疗效果及预后的关系  

Relationship between Serum Thymidine Kinase 1 and SCC-Ag Levels and Treatment Effect and Prognosis of Cervical Squamous Cell Carcinoma

作　　者：梁春燕 郑瑞芳 陈瑞芬 曹清丽 杨帆 孙海时 黄艳萍 LIANG Chunyan;ZHENG Ruifang;CHEN Ruifen;CAO Qingli;YANG Fan;SUN Haishi;HUANG Yanping(Department of Gynaecology,Shaoguan First People's Hospital,Shaoguan,Guangdong Province,512000 China)

机构地区：[1]韶关市第一人民医院妇科,广东韶关512000

出　　处：《系统医学》2023年第19期24-27,共4页Systems Medicine

基　　金：韶关市卫生健康科研项目(Y22177)。

摘　　要：目的探究不同临床病理特征宫颈鳞癌患者血清胸苷激酶1(thymidine kinase 1,TK-1)与鳞状细胞癌抗原(sguamous cell carcinoma associated antigen,SCC-Ag)水平的表达变化。方法选取2020年1月—2021年3月韶关市第一人民医院收治的80例宫颈鳞癌患者为观察组,同时期的80例宫颈良性病变患者为对照组,检测及比较两组患者的血清TK-1与SCC-Ag水平,并比较不同淋巴结转移情况、国际妇产科联盟宫颈癌临床(International Federation of Gynecology and Obstetrics,FIGO)分期、分化程度、局部复发情况、死亡情况及脉管浸润情况宫颈鳞癌患者的检测水平。结果观察组的血清TK-1与SCC-Ag分别为(2.98±0.86)pmol/L及(3.21±0.79)ng/mL,显著高于对照组的(0.50±0.20)pmol/L及(0.71±0.22)ng/mL,差异有统计学意义(t=25.122,27.267,P<0.001),不同淋巴结转移情况、FIGO分期、分化程度、局部复发情况、死亡情况及脉管浸润情况宫颈癌者的血清TK-1与SCC-Ag水平比较,差异有统计学意义(P<0.05)。结论宫颈鳞癌患者的血清TK-1与SCC-Ag呈现高表达状态,且不同临床病理特征患者的表达差异显著。Objective To investigate the changes of serum thymidine kinase 1(TK-1)and sguamous cell carcinoma associated antigen(SCC-Ag)in patients with cervical squamous cell carcinoma with different clinicopatholgical features.Methods 80 patients with cervical squamous cell carcinoma from Shaoguan First People's Hospital from January 2020 to March 2021 were selected as the observation group,and 80 patients with cervical benign lesions during the same period were selected as the control group.Serum TK-1 and SCC-Ag levels were detected and compared between the two groups,and the detection levels of cervical squamous cell carcinoma patients with different lymph node metastasis,International Federation of Gynecology and Obstetrics(FIGO)stage,differentiation degree,local recurrence,death and vascular invasion were compared.Results Serum TK-1 and SCC-Ag levels in the observation group were(2.98±0.86)pmol/L and(3.21±0.79)ng/mL,respectively,which were significantly higher than those in the control group(0.50±0.20)pmol/L and(0.71±0.22)ng/mL,and the differences were statistically significant(t=25.122,27.267,P<0.001).The serum TK-1 and SCC-Ag levels of cervical cancer patients with different lymph node metastasis,FIGO stage,differentiation degree,local recurrence,death and vascular invasion,the differences were statistically significant(P<0.05).Conclusion Serum TK-1 and SCC-Ag were highly expressed in patients with cervical squamous cell carcinoma,and the expression was significantly different in patients with different clinicopathological characteristics.

关 键 词：胸苷激酶-1 鳞状细胞癌抗原 宫颈鳞癌 临床病理特征 

分 类 号：R711.74[医药卫生—妇产科学] R392.7[医药卫生—临床医学]