常州地区中老年妇女骨质疏松症的危险因素分析  

Risk Factors of Osteoporosis in Middle-aged and Elderly Women in Changzhou

作　　者：宋庆明[1] 杨一文[1] 周云庆[2] SONG Qingming;YANG Yiwen;ZHOU Yunqing(Department of Endocrinology,Changzhou Hospital of Traditional Chinese Medicine,Changzhou,Jiangsu Province,213000 China;Department of Education and Training,Changzhou Hospital of Traditional Chinese Medicine,Chang-zhou,Jiangsu Province,213000 China)

机构地区：[1]常州市中医医院内分泌科,江苏常州213000 [2]常州市中医医院教培处,江苏常州213000

出　　处：《系统医学》2023年第19期70-73,共4页Systems Medicine

基　　金：常州市卫生健康委青年人才科技项目(QN201940)。

摘　　要：目的分析常州地区中老年妇女骨质疏松症的患病率以及危险因素,指导临床筛查高危患者并进行适当干预。方法采用病例对照研究的方法,随机选择2020年1月—2021年6月于常州市中医医院就诊女性患者共243例为研究对象,根据双能X线骨密度仪测量腰椎和髋部骨密度值,将其分为骨质疏松组92例(T值≤-2.5 SD)和无骨质疏松组151例(T值>-2.5 SD)。比较两组年龄、绝经时间、妊娠次数、体质指数、腰围和腰臀比、是否肥胖和肥胖类型、每周运动时间、是否饮用牛奶、是否口服钙剂、基础疾病、血清甲状腺激素、骨转换生化标志物情况。结果单因素方差分析发现,骨质疏松组年龄、绝经时间、腰臀比、腹型肥胖,基础疾病比例、Ⅰ型胶原交联羧基末端肽(type I collagen cross-linked carboxyl terminal peptid,CTX)均高于无疏松组,而运动时间、口服钙剂比例明显低于无骨质疏松组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,年龄(OR=1.486,P<0.001)、腰臀比(OR=1.752,P=0.027)及CTX值(OR=1.007,P=0.047)是中老年妇女骨质疏松症的独立危险因素,运动时间(OR=0.985,P=0.008)是骨质疏松的保护因素。结论筛查中老年妇女骨质疏松症的主要危险因素,可以指导临床识别高危患者并进行合理干预。Objective To analyze the prevalence rate and risk factors of osteoporosis in middle-aged and elderly women in Changzhou,and guide clinical screening of high-risk patients and appropriate intervention.Methods A total of two hundred and forty-three female patients who received medical treatment in Changzhou Hospital of Traditional Chinese Medicine from January 2020 to June 2021 were randomly selected as the study subjects according to the.They were divided into osteoporosis group(92 cases)(T-value≤-2.5 SD)and non-osteoporosis group(151 cases)(T-value>-2.5 SD).Age,time of menopause,number of pregnancies,body mass index,waist circumference and waist-to-hip ratio,obesity and obesity type,weekly exercise time,milk consumption,oral calcium ingestion,underlying diseases,serum thyroid hormone and biochemical markers of bone turnover were compared between the two groups.Results One-factor ANOVA showed that age,menopause time,waist-to-hip ratio,abdominal obesity,proportion of underlying diseases,and type I collagen cross-linked carboxyl terminal peptide(CTX)in the osteoporosis group were higher than those in the non-osteoporosis group,while exercise time and proportion of oral calcium were significantly lower than those in the non-osteoporosis group,and the differences were statistically significant(P<0.05).Multivariate logistic regression analysis showed that age(OR=1.486,P<0.001),waist-to-hip ratio(OR=1.752,P=0.027)and CTX value(OR=1.007,P=0.047)were independent risk factors for osteoporosis in middle-aged and elderly women.Adequate exercise time(OR=0.985,P=0.008)was a protective factor for osteoporosis.Conclusion Screening the main risk factors of osteoporosis in middle-aged and elderly women can guide clinical identification of high-risk patients and reasonable intervention.

关 键 词：骨质疏松症 危险因素 骨转换生化标志物 

分 类 号：R580[医药卫生—内分泌]