差示扫描量热分析法在药物熔点测定实验中的应用  

Application of Differential Scanning Calorimetry in Drug Melting Point Determination Experiments

作　　者：陈艳 李文戈 曹凤龙 梁丽丽 张恩立 CHEN Yan;LI Wen-ge;CAO Feng-long;LIANG Li-li;ZHANG En-li(Public Foundation College,Bengbu Medical College,Bengbu 233030,China)

机构地区：[1]蚌埠医学院公共基础学院,安徽蚌埠233030

出　　处：《长春师范大学学报》2023年第12期93-97,共5页Journal of Changchun Normal University

基　　金：安徽省质量工程项目“课程思政示范课”(2020szsfkc0612);安徽省高校省级重大教改项目“医学院校公共基础课课程思政建设研究与实践”(2020jyxm1169);安徽省质量工程重大教学研究项目“协同育人模式下制药工程专业毕业设计实践体系质量监控研究”(2020jyxm1171);安徽省质量工程重大教学研究项目“面向新工科建设的青年教师培养模式改革与创新研究”(2017jyxm0248)。

摘　　要：差示扫描量热(DSC)分析法是一种常用的材料科学分析方法,该方法快速、简单、可靠,可用于药物熔点的测定,对药物的纯度和结晶度进行评估。鉴于学生传统毛细管法在药物熔点测定中的不足,本文以苯佐卡因药物合成实验为例,探讨现代差示扫描量热分析法在熔点测定实验中的应用,由此加深学生对药物合成实验的理解,培养学生的综合实验技能和解决问题的能力,增强现代分析技术在本科生实验教学中的应用,提高教学质量的同时,增强本科生的科研素养和实践能力。Differential scanning calorimetry(DSC)is a commonly used material science analysis method,which is fast,simple,and reliable.It can be used to determine the melting point of drugs and evaluate the purity and crystallinity of drugs.Considering the shortcomings of traditional capillary method in drug melting point determination among students,this article takes the experiment of benzocaine drug synthesis as an example to explore the application of modern differential scanning calorimetry analysis in melting point determination experiments.This will deepen students’understanding of drug synthesis experiments,cultivate their comprehensive experimental skills and problem-solving abilities,enhance the application of modern analytical technology in undergraduate experimental teaching,and improve teaching quality,Enhance undergraduate students’scientific research literacy and practical abilities.

关 键 词：差示扫描量热分析法 熔点 苯佐卡因 合成实验 

分 类 号：R917[医药卫生—药物分析学]