醒脑静注射液治疗急性脑卒中意识障碍患者疗效研究  

The therapeutic effect of Xingnaojing Injection on patients with acute stroke consciousness disorder

作　　者：狄咏赟 李君 沈颖[3] DI Yong-yun;LI Jun;SHEN Ying(Pharmacy Department,People’s Hospital of Liyang,Liyang 213300;Department of Pharmacy,Nanjing Xixia District Hospital,Nanjing 210046;Department of Pharmacy,People’s Hospital of Yixing,Yixing 214200)

机构地区：[1]江苏省溧阳市人民医院药剂科,江苏溧阳213300 [2]江苏省南京市栖霞区医院药剂科,江苏南京210046 [3]江苏省宜兴市人民医院药学部,江苏宜兴214200

出　　处：《湖北中医药大学学报》2023年第6期19-22,共4页Journal of Hubei University of Chinese Medicine

基　　金：江苏省药学会-奥赛康医院药学基金科研项目(项目编号:A202045)。

摘　　要：目的 观察醒脑静注射液治疗急性脑卒中意识障碍(ASCD)患者临床疗效。方法 将我院128例ASCD患者随机分为观察组与对照组各64例。对照组采用纳洛酮注射液治疗,观察组采用纳洛酮注射液联合醒脑静注射液治疗。比较分析两组患者总有效率,评价美国国立卫生研究院卒中量表(NIHSS)、格拉斯哥评分(GSC)、修订版昏迷恢复量表(CRS-R)评分;记录意识恢复时间、住院时间、心血管不良事件发生情况监测体温;检测白细胞计数(WBC)、中性粒细胞计数(NEU)、超敏-C反应蛋白(hs-CRP)、神经元特异性烯醇化酶(NSE)的水平。结果 治疗后,观察组总有效率高于对照组(P<0.05);两组NHSS评分低于治疗前,GSC和CRS-R评分高于治疗前,观察组NHSS评分低于对照组,GSC和CRS-R评分高于对照组(P<0.05);观察组意识恢复时间、住院时间、心血管不良事件发生情况均少于对照组(P<0.05);两组体温、WBC、NEU、hs-CRP、NSE水平低于治疗前,观察组体温、WBC、NEU、hs-CRP、NSE水平低于对照组(P<0.05)。结论 醒脑静注射液应用于ASCD患者疗效满意,可提高神经功能,促进意识恢复,作用机制与炎症反应下调、NSE水平下降有关。Objective To observe the therapeutic effect of Xingnaojing Injection on patients with acute stroke consciousness disorder(ASCD).Methods A total of 128 ASCD patients were randomly divided into observation group and control group,with 64 cases in each group.Control group was treated with Naloxone Injection,while observation group was treated with Xingnaojing Injection on the baiss of control group.The total effective rate of two groups were compared and analyzed,the National Institutes of Health Stroke Scale(NIHSS)score,Glasgow Scale(GSC)score,and Revised Coma Recovery Scale(CRS-R)score were evaluated;the time of consciousness recovery,hospitalization time,and incidence of cardiovascular adverse events were recorded;the body temperature were monitored and the levels of white blood cell count(WBC),neutrophil count(NEU),hypersensitive C-reactive protein(hs-CRP)and neuron specific enolase(NSE)detected.Results After treatment,the total effective rate of observation group was higher than that of control group(P<0.05);the NHSS scores of both groups were lower than before treatment,and was lower in observation group than control group,while the GSC and CRS-R scores were higher,and were higher in observation group than control group(P<0.05);the consciousness recovery time,hospitalization time,and the incidence of cardiovascular adverse events in observation group were all lower than those in control group(P<0.05);the body temperature,WBC,NEU,hs-CRP,and NSE levels in both groups were lower than before treatment,and were lower in observation group than control group(P<0.05).Conclusion Xingnaojing Injection has a satisfactory therapeutic effect on ASCD patients,improving neurological function and promoting consciousness recovery.The mechanism of action is related to the down-regulation of inflammatory response and the decrease in NSE levels.

关 键 词：急性脑卒中 意识障碍 醒脑静注射液 

分 类 号：R259[医药卫生—中西医结合]