难治性幻听精神分裂症患者静息态脑电特异性特征分析  

Analysis of Resting-State EEG Specific Characteristics in Schizophrenic with Refractory Auditory Hallucination

作　　者：刘爽 廖婧萌 王孝娟 李美娟[2] 高营[2] 李洁[2] 明东 Liu Shuang;Liao Jingmeng;Wang Xiaojuan;Li Meijuan;Gao Ying;Li Jie;Ming Dong(Academy of Medical Engineering and Translational Medicine,Tianjin University,Tianjin 300072,China;Department of Psychiaty,Tianjin Anding Hospital,Tjanjin 300202,China)

机构地区：[1]天津大学医学工程与转化医学研究院,天津300072 [2]天津市安定医院精神科,天津300202

出　　处：《中国生物医学工程学报》2023年第5期513-519,共7页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(81801786,81925020)。

摘　　要：精神分裂症是一种严重危害人类身心健康的重性精神疾病,幻听是其核心症状之一,约有30%的幻听患者经药物治疗后仍无法痊愈,称为难治性幻听(RAH)。为探究难治性幻听的形成机制及患者的大脑活动特点,30名难治性幻听患者与30名非难治性幻听患者(NRAH)被纳入研究。采用8 min睁闭眼静息范式,任务同时采集被试64导静息态脑电数据,接着通过功率谱和源定位分析分别计算了两组被试的静息脑电6个频段的绝对功率和皮层脑电分布情况。结果显示,δ频段在右侧颞上回、颞中回、颞上沟、角回处较NRAH组有更强激活,但全脑平均功率显著低于NRAH组(p(RAH)=64.05±116.82,p(NRAH)=110.40±125.56,P<0.01);低γ频段(p(RAH)=7.14±14.88,p(NRAH)=8.99±10.13,P<0.05)和高γ频段绝对功率(p(RAH)=11.46±17.48,p(NRAH)=30.12±46.88,P<0.01)也显著低于NRAH组,且二者在颞中回、颞上回到颞顶叶、额顶叶交界处激活强度和范围均低于NRAH组,且缺少NRAH组所存在的偏侧化现象。综上,δ频段、低γ频段和高γ频段可能为难治性幻听的潜在生理指标,且难治性幻听的形成机制可能与慢波(尤其是δ频段)在颞叶的过度激活和高频振荡(尤其是γ频段)在颞叶的失活有关。本研究的结果可为探究难治性幻听患者的脑活动特点和难治性幻听的患病机理提供有效的客观依据,具有一定的理论意义和临床价值。Schizophrenia is a heavy mental disease that seriously harms human physical and mental health.Auditory hallucination is one of core symptoms for schizophrenia,about 30%of patients with auditory hallucinations cannot be cured by drug treatment,called refractory auditory hallucinations(RAH).In order to explore the formation mechanism of refractory auditory hallucinations and the characteristics of their brain activity,30 patients with refractory auditory hallucinations and 30 patients with non-refractory auditory hallucinations(NRAH)were enrolled.In this study,the 8-minute resting paradigm with eyes open and closed was adopted,and 64 channels of EEG(electroencephalography)data was collected at the same time.Then the absolute power spectrum of six frequency bands and the distribution of cortical EEG of the two groups were calculated by power spectrum and source localization analysis.Experimental results showed that theδband was more activated in the right superior temporal gyrus,middle temporal gyrus,superior temporal sulcus and angular gyrus in RAH than in NRAH,but the average power of whole brain was significantly lower than that of NRAH group(p(RAH)=64.05±116.82,p(NRAH)=110.40±125.56,P<0.01).The absolute power of low-γ(p(RAH)=7.14±14.88,p(NRAH)=8.99±10.13,P<0.05)and high-γ(p(RAH)=11.46±17.48,p(NRAH)=30.12±46.88,P<0.01)was significantly lower than that of NRAH,and the intensity and range of activation of them in the middle temporal gyrus,superior temporal to temporoparietal lobe,and frontoparietal junction were lower than those in NRAH,and the phenomenon of lateralization was absent in NRAH.In conclusion,δ,low-γ and high-γ may be potential physiological indicators of refractory auditory hallucinations,and the formation mechanism of refractory auditory hallucinations may be related to the overactivation of slow waves(especially δ)in the temporal lobe and the inactivation of high-frequency oscillations(especially γ)in the temporal lobe.The results of this study can provide effective objective basis for

关 键 词：静息态脑电 精神分裂症 幻听 绝对功率 源定位 

分 类 号：R318[医药卫生—生物医学工程]