脊髓电刺激治疗帕金森病步态冻结症状的电生理学研究进展  

Advances in Electrophysiological Research of Spinal Cord Stimulation on Freezing of Gait in Parkinson′s Disease

作　　者：李梓赟 李继平[2] 魏婧 Li Ziyun;Li Jiping;Wei Jing(School of Biomedical Engineering,Capital Medical University,Bejing 100069,China;Department of Functional Neurosurgery,Xuanwu Hospital,Capital Medical University,Bejing 100053,China)

机构地区：[1]首都医科大学生物医学工程学院,北京100069 [2]首都医科大学宣武医院功能神经外科,北京100053

出　　处：《中国生物医学工程学报》2023年第5期603-609,共7页Chinese Journal of Biomedical Engineering

基　　金：北京市教育委员会科学研究计划项目资助(KM202210025023);首都医科大学学生科研创新项目(XSKY2022176);吴阶平医学基金会(320.6750.19089-78)。

摘　　要：步态冻结(FoG)是帕金森病(PD)的一种严重症状,发病率高,且严重影响患者的生活,目前尚无理想的治疗方法。脊髓电刺激(SCS)是对脊髓进行电刺激的一种治疗手段,具有创伤小的优势。从SCS技术改善FoG的电生理学治疗机制角度,首先介绍FoG的异常解剖结构机制,其次从皮层和深脑层面综述FoG的异常电生理学研究进展,然后从临床和动物模型两个角度综述SCS调控FoG的电生理学机制,最后总结目前SCS存在的局限性与不足,进一步探讨SCS用于治疗FoG的应用前景、可能的改进方向以及未来的发展趋势。Freezing of gait(FoG)is a severe symptom of Parkinson's disease(PD),which has a high incidence rate and seriously affects the quality of life of patients.Currently,there are no ideal methods for the treatment of FoG.Spinal cord stimulation(SCS)is a therapeutic way of electrical stimulation of the spinal cord,which has the advantage of causing less surgical trauma.From the perspective of SCS technology to improve the electrophysiological treatment mechanism of FoG,this paper first introduced the abnormal anatomical mechanism of FoG,followed by reviewing the research progress of abnormal electrophysiology of FoG from the level of cortex and deep brain,and then discussed the electrophysiological mechanism of SCS regulation of FoG from the clinical and animal models.Finally,we summarized the limitations and deficiencies of the current SCS and explored application prospects,possible improvement directions,and future development trends of SCS in the treatment of FoG.

关 键 词：步态冻结 脊髓电刺激 电生理机制 帕金森病 

分 类 号：R318[医药卫生—生物医学工程]