胎膜早破产妇胎膜组织中NAMPT及血清β-HCG和SFRP5表达与绒毛膜羊膜炎感染的关系  

Relationship between the expression of NAMPT,serum β-HCG,SFRP5 and chorioamnitis in the fetal membranes of women with premature rupture of membranes

作　　者：陈艳洁 张霞 陈琼颖 应家琪 周晗薇 唐禹馨 CHEN Yan-jie;ZHANG Xia;CHEN Qiong-ying;YING Jia-qi;ZHOU Han-wei;TANG Yu-xin(Zhoushan Women and Children's Hospital,Zhoushan,Zhejiang 316000,China)

机构地区：[1]舟山市妇女儿童医院产科,浙江舟山316000

出　　处：《中华医院感染学杂志》2023年第23期3635-3639,共5页Chinese Journal of Nosocomiology

基　　金：浙江省科研项目补助计划(2021SJ3022)。

摘　　要：目的研究胎膜早破产妇合并绒毛膜羊膜炎感染的影响因素及其与胎膜组织中烟酰胺磷酸核糖转移酶(NAMPT)及血清β-绒毛膜促性腺激素(β-HCG)、分泌型卷曲相关蛋白5(SFRP5)表达的关系。方法回顾性选取2019年1月-2022年12月舟山市妇女儿童医院收治的40例合并绒毛膜羊膜炎感染的胎膜早破产妇为绒毛膜羊膜炎组,选取同期医院收治的64例未合并绒毛膜羊膜炎感染的胎膜早破产妇为非绒毛膜羊膜炎组,统计胎膜早破产妇合并绒毛膜羊膜炎感染的单因素,采用Logistic回归分析胎膜早破产妇合并绒毛膜羊膜炎感染的影响因素,比较两组胎膜组织中NAMPT及血清β-HCG、SFRP5表达情况,采用受试者工作特征(ROC)曲线分析胎膜组织中NAMPT及血清β-HCG、SFRP5对胎膜早破产妇合并绒毛膜羊膜炎感染的预测价值。结果多因素Logistic回归分析结果显示,破膜孕周<32周、破膜时间≥48 h、羊水过少均为胎膜早破产妇合并绒毛膜羊膜炎感染的独立危险因素(P<0.05);绒毛膜羊膜炎组胎膜组织中NAMPT及血清β-HCG表达水平均高于非绒毛膜羊膜炎组,血清SFRP5表达水平低于非绒毛膜羊膜炎组(P<0.05);胎膜组织中NAMPT及血清β-HCG、SFRP5联合预测胎膜早破产妇合并绒毛膜羊膜炎感染曲线下面积(AUC)值、特异度高于三者单独检测(P<0.05)。结论胎膜早破产妇合并绒毛膜羊膜炎感染的独立危险因素较多,而胎膜组织中NAMPT及血清β-HCG、SFRP5联合对胎膜早破产妇合并绒毛膜羊膜炎感染的预测价值较好。OBJECTIVE To study the influencing factors for chorionic amnitis infection in women with premature rupture of fetal membrane and the correlation of niacinamide phosphate ribose transferase(NAMPT),serum β-chorionic gonadotropin(β-HCG)and secreted frizzy-associated protein 5(SFRP5)with the infection.METHODS Total of 40 women with premature rupture of membranes complicated with chorioamnitis infection admitted to Zhoushan Women and Children′s Hospital from Jan 2019 to Dec 2022 were recruited as the chorioamnitis group,and 64 women with premature rupture of membranes without chorioamnitis infection admitted to the hospital during the same period were selected as the non-chorioamnitis group.The risk factors of chorioamnitis infection in women with premature rupture of fetal membrane were analyzed by univariate and multivariate logistic regression analysis.The expression levels of NAMPT in fetal membrane tissue and serum β-HCG and SFRP5 were compared between the two groups.The predictive value of NAMPT in fetal membrane tissue,serum β-HCG and SFRP5 in women with premature rupture of fetal membrane and chorioamnitis was analyzed by receiver operating characteristic(ROC)curve.RESULTS Multivariate logistic regression analysis showed that pregnant women with premature rupture of membranes<32 weeks,rupture of membranes≥48 h,oligohyniotic fluid were independent risk factors for chorionic amnitis infection(P<0.05).The levels of NAMPT in fetal membrane tissue and serum β-HCG and SFRP5 of chorionic amniotic infection group were higher than those of non-chorionic amniotic infection group,while the levels of serum SFRP5 was lower than those of non-chorionic amniotic infection group(P<0.05).The area under the curve(AUC)and specificity of NAMPT combined with serum β-HCG and SFRP5 detection in the fetal membrane tissues were higher than those of the three tests alone(P<0.05).CONCLUSION There are many independent risk factors for chorioamniotic infection in women with premature rupture of membranes,and the combination of NA

关 键 词：胎膜早破 绒毛膜羊膜炎 影响因素 烟酰胺磷酸核糖转移酶 Β-绒毛膜促性腺激素 分泌型卷曲相关蛋白5 预测价值 

分 类 号：R714.433[医药卫生—妇产科学]