D-D与sCD14-ST及SDF-1对感染性骨不连的诊断价值  

Diagnostic value of D-D, sCD14-ST and SDF-1 in infected nonunion

作　　者：王振龙 刘勇 刘炳 许玉林 WANG Zhen-long;LIU Yong;LIU Bing;XU Yu-lin(Southwest Medical University Affiliated Traditional Chinese Medicine Hospital,Luzhou,Sichuan 646000,China;不详)

机构地区：[1]西南医科大学附属中医医院骨伤科,四川泸州646000 [2]西南医科大学附属医院骨科,四川泸州646000

出　　处：《中华医院感染学杂志》2023年第24期3766-3770,共5页Chinese Journal of Nosocomiology

基　　金：四川省自然科学基金资助项目(C2018ZB115)。

摘　　要：目的 探讨血清D-二聚体(D-D)、可溶性白细胞分化抗原14亚型(sCD14-ST)、基质细胞衍生因子-1(SDF-1)对感染性骨不连的诊断价值。方法 回顾性选取2020年1月-2022年12月西南医科大学附属中医医院骨伤科收治的感染性骨不连患者作为感染性骨不连组(80例),无菌性骨不连患者作为无菌性骨不连组(82例),另根据受试者工作特征(ROC)曲线截断值将感染性骨不连组患者血清D-D分为高表达组(45例)和低表达组(35例),血清sCD14-ST分为高表达组(48例)和低表达组(32例),血清SDF-1分为高表达组(43例)和低表达组(37例),比较感染性骨不连组和无菌性骨不连组血清D-D、sCD14-ST、SDF-1水平,分析血清D-D、sCD14-ST、SDF-1单独及联合检测对感染性骨不连的诊断价值,比较血清D-D、sCD14-ST、SDF-1高表达组、低表达组感染性骨不连患者感染评分,用Pearson相关性系数分析血清D-D、sCD14-ST、SDF-1水平与感染评分的相关性。结果 感染性骨不连组血清D-D、sCD14-ST、SDF-1水平均高于无菌性骨不连组(P<0.05);ROC曲线分析结果显示,血清D-D、sCD14-ST、SDF-1联合检测诊断感染性骨不连的曲线下面积(AUC)值为0.932,高于血清D-D、sCD14-ST、SDF-1单独检测(P<0.05);血清D-D、sCD14-ST、SDF-1高表达组感染评分均高于低表达组(P<0.05);Pearson相关性分析结果显示,血清D-D、sCD14-ST、SDF-1水平与感染评分均呈正相关(P<0.05)。结论 血清D-D、sCD14-ST、SDF-1与感染性骨不连患者感染程度密切相关,三者联合检测对感染性骨不连的诊断价值更高。OBJECTIVE To investigate the diagnostic value of serum D-Dimer(D-D), soluble leukocyte differentiation antigen subtype 14(sCD14-ST) and stromal cell-derived factor-1(SDF-1) levels in infectious nonunion. METHODS Patients with infectious nonunion admitted to the department of orthopaedics and traumatology in the Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University from Jan 2020 to Dec 2022 were retrospectively recruited as the infectious nonunion group(80 cases), and patients with aseptic nonunion were selected as the aseptic nonunion group(82 cases). According to the receiver operating characteristic curve(ROC) cut-off value of serum D-D in the infective nonunion group was subdivided into the D-D high expression group(45 cases), D-D low expression group(35 cases), sCD14-S high expression group(48 cases), the sCD14-S low expression group(32 cases), SDF-1 high expression group(43 cases) and SDF-1 low expression group(37 cases). Levels of serum D-D, sCD14-ST and SDF-1 were compared between the infected nonunion group and the aseptic nonunion group. The diagnostic value of serum D-D, sCD14-ST and SDF-1 individual and combined detection in infected nonunion was analyzed. The score of infection of patients with infected nonunion were compared between the high and low expression groups of serum D-D, sCD14-ST and SDF-1. Pearson correlation analysis was used to analyze the correlation between levels of serum D-D, sCD14-ST, SDF-1 and scores of infection. RESULTS The serum levels of D-D, sCD14-ST and SDF-1 in the infected nonunion group were higher than those in the aseptic nonunion group(P<0.05). ROC curve analysis showed that the area under the curve(AUC) value of serum D-D, sCD14-ST and SDF-1 combined detection in the diagnosis of infected nonunion was 0.932, which was higher than that of individual detection(P<0.05). The infection score of serum D-D, sCD14-ST and SDF-1 in the high expression group was higher than that in the low expression group(P<0.05). Pearson correlation analysis showed th

关 键 词：感染性骨不连 D-二聚体 可溶性白细胞分化抗原14亚型 基质细胞衍生因子-1 诊断价值 

分 类 号：R604[医药卫生—外科学]