气管食管瘘临床诊疗研究进展  

Progress in clinical diagnosis and treatment of tracheoesophageal fistulas

作　　者：吴彤 周云芝 徐淑凤[3] 杨胜波 Wu Tong;Zhou Yun-Zhi;Xu Shu-Feng;Yang Sheng-Bo(Department of Human Anatomy,Zunyi Medical University,Zunyi,Guizhou 563003,China;Department of Respiratory Medicine,Beijing Emergency General Hospital,Beijing 100028,China;Department of Respiratory and Critical Care Medicine,the First Hospital of Qinhuangdao,Qinhuangdao,Hebei 066000,China)

机构地区：[1]遵义医科大学人体解剖学教研室,贵州遵义563003 [2]北京市应急总医院呼吸内科,北京100028 [3]秦皇岛市第一医院呼吸与危重症医学科,河北秦皇岛066000

出　　处：《解放军医学杂志》2023年第12期1473-1477,共5页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(32260217);河北省自然科学基金(H2021107002)。

摘　　要：气管食管瘘是指气管或支气管与食管之间的病理性瘘道,包括气管-食管瘘和支气管-食管瘘,临床以气管-食管瘘较多见。气管食管瘘致病原因较多,可引起严重的并发症,影响生活质量,是一种治疗困难、病死率较高的疾病。气管食管瘘目前治疗方式较多,但多数疗效欠佳,对新兴治疗手段的需求迫切。胸腹部X线摄影检出鼻胃管滞留是气管食管瘘诊断的金标准,其主要治疗方法包括外科手术治疗、支架置入、局部生物胶水封闭、干细胞治疗等。本文综述近年气管食管瘘诊断与治疗的主要研究进展,旨在为该病的临床诊治提供参考。Tracheoesophageal fistulas(TEF)is a kind of pathological fistula between trachea or bronchus and esophagus,including tracheoesophageal fistula and bronchoesophageal fistula.In clinical practice,tracheoesophageal-fistula is more often seen.There are many pathogenesis of TEF,which could cause serious complications.It is a disease which has serious impact on the quality of life,difficult to treat and high mortality.There are many methods to treat TEF,but the therapeutic effect is poor.There is an urgent need for new treatment methods to TEF.The detection of nasogastric tube retention by chest and abdominal X-ray is the gold standard for diagnosis.The main treatment methods include surgical treatment,stent implantation,local biological glue blocking,stem cell therapy and so on.In order to provide reference for relevant clinical diagnosis and treatment of TEF,this article reviews the main research progress in the diagnosis and treatment of TEF in recent years.

关 键 词：气管食管瘘 支架 生物蛋白胶 干细胞 再生医学 

分 类 号：R562.1[医药卫生—呼吸系统] R655[医药卫生—内科学]