2型糖尿病合并非酒精性脂肪性肝病患者血尿酸水平变化及临床意义  

Changes and clinical significance of serum uric acid level in type 2 diabetes patients with nonalcoholic fatty liver disease

作　　者：熊琦君 朱雯[1] XIONG Qi-jun;ZHU Wen(Department of Laboratory,Wuxi Traditional Chinese Medicine Hospital,Jiangsu 214000,China)

机构地区：[1]无锡市中医医院检验科,江苏214000

出　　处：《肝脏》2023年第12期1476-1479,共4页Chinese Hepatology

基　　金：无锡市中医医院院内项目(ZYYYB21012)。

摘　　要：目的观察血尿酸水平在2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)患者中的变化,并分析其临床意义。方法选取无锡市中医医院2020年12月至2022年12月收治的T2DM患者118例,按照是否并发NAFLD分为合并组(n=88)与非合并组(n=30)。logistic回归分析T2DM合并NAFLD的影响因素。结果合并组、非合并组BMI为(26.72±2.53)kg/m 2、(23.31±2.17)kg/m 2,差异有统计学意义(P<0.05);合并组空腹血糖、HOMA-IR为(8.82±1.45)mmol/L、(3.58±0.95)mmol/L,均高于非合并组的(7.67±1.23)mmol/L、(3.05±0.79)mmol/L,(P<0.05);合并组ALT、AST、总胆固醇、三酰甘油及LDL为(37.94±2.68)U/L、(29.20±2.61)U/L、(5.38±1.13)mmol/L、(2.46±0.64)mmol/L及(3.31±0.80)mmol/L,均高于非合并组的(23.27±2.16)U/L、(21.71±2.03)U/L、(4.34±1.02)mmol/L、(1.32±0.55)mmol/L及(2.56±0.62)mmol/L;合并组血尿酸为(349.14±28.45)μmol/L,高于非合并组的(273.34±17.29)μmol/L,(P<0.05);合并组LDL为(1.35±0.38)mmol/L,低于非合并组的(2.29±0.43)mmol/L,(P<0.05)。多因素分析结果提示BMI、HOMA-IR以及血尿酸是T2DM并发NAFLD的危险因素(OR值分别为4.604、5.150、4.978,P<0.05)。结论T2DM患者可能并发NAFLD,BMI、HOMA-IR以及血尿酸为其主要危险因素。Objective To observe the variations in serum uric acid levels among patients with type 2 diabetes mellitus(T2DM)and nonalcoholic fatty liver disease(NAFLD)and assess its clinical implications.Methods Between December 2020 and December 2022,118 patients with T2DM admitted to our hospital were selected,including 64 males and 54 females,aged(57.78±4.07)years.Based on the presence or absence of NAFLD complications,patients were divided into combined group(n=88)and non-combined group(n=30).A retrospective study was carried out.Variables showing statistical differences were subjected to multivariate Logistic regression analysi.Results The BMI for the combined group was(26.72±2.53)kg/m 2,while it was(23.31±2.17)kg/m 2 for the non-combined group.The difference was statistically significant(P<0.05).The fasting blood glucose and HOMA-IR levels in the combined group were(8.82±1.45)mmol/L and(3.58±0.95),respectively,which were significantly higher than those in the non-combined group[(7.67±1.23)mmol/L and(3.05±0.79),P<0.05].The levels of ALT,AST,total cholesterol,triglyceride and LDL in the combined group were(37.94±2.68)U/L,(29.20±2.61)U/L,(5.38±1.13)mmol/L,(2.46±0.64)mmol/L and(3.31±0.80)mmol/L,respectively.In comparison,the non-combined group had values of(23.27±2.16)U/L,(21.71±2.03)U/L,(4.34±1.02)mmol/L,(1.32±0.55)mmol/L and(2.56±0.62)mmol/L.The difference between the groups was statistically significant(P<0.05).The serum uric acid in the combined group was(349.14±28.45)μmol/L,compared to(273.34±17.29)μmol/L in the non-combined group,and the difference was statistically significant(P<0.05).Additionaly,the LDL level in the combined group was(1.35±0.38)mmol/L,which was significantly lower than the(2.29±0.43)mmol/L observed in the non-combined group(P<0.05).According to the multivariate Logistic regression analysis,when incorporating the above differences into the study,it was suggested that BMI,HOMA-IR and serum uric acid were risk factors for T2DM complicated with NAFLD(OR values were 4.604,5.150 an

关 键 词：T2DM NAFLD 血尿酸 

分 类 号：R587.2[医药卫生—内分泌] R575.5[医药卫生—内科学]