The effect of antioxidants on increased oocyte Competence in IVM: a review  

作　　者：Arezoo Solati Sina Taghvimi Zeinab Jamali Farzaneh Vahedi Mostafa Moazamfard Sedigheh Bahmyari Ahmad Movahedpour Hassan Ghasemi 

机构地区：[1]Department of Reproductive Biology,School of Advanced Medical Sciences and Technologies,Shiraz University of Medical Sciences,Shiraz,Iran [2]Department of Biology,Faculty of Science,Shahid Chamran University of Ahvaz,Ahvaz,Iran [3]Department of Medical Genetics,School of Medicine,Tehran University of Medical Sciences,Tehran,Iran [4]Department of Medical Biotechnology,School of Advanced Medical Sciences and Technologies,Shiraz University of Medical Sciences,Shiraz,Iran [5]Department of Operating Room,Faculty of Paramedicine,Behbahan University of Medical Sciences,Behbahan,Iran [6]Behbahan Faculty of Medical Sciences,Behbahan,Iran [7]Abadan University of Medical Sciences,Abadan,Iran.

出　　处：《Reproductive and Developmental Medicine》2023年第3期180-188,共9页生殖与发育医学（英文版）

基　　金：financially supported by the Abadan University of Medical Sciences,Abadan,Iran(1401U-1467).

摘　　要：In vitro maturation(IVM)is considered a potential assisted reproductive technology that is a safer and simpler alternative to conventional in vitro fertilization.It is primarily used in patients with impaired oocyte maturation and for the treatment of infertile women who are at risk of fertility loss.In addition,IVM is currently used mainly in polycystic ovarian syndrome patients with a high ovarian response and is stll considered an experimental option in fertility preservation.Producing highly competent oocytes during IVM is considered a key step in the success of in vitro production(IVP)of embryos.Some factors,such as culture medium conditions and other supplements,have a significant impact on oocyte IVM performance.One of the known disruptors of oocyte developmental competence in IVP is oxidative stress(Os),which is caused by an imbalance between the production and neutralization of reactive oxygen species(ROS).In vitro conditions induce supraphysiological ROS levels due to exposure to an oxidative environment and the isolation of the oocyte from the follicle protective antioxidant milieu.Given the importance of Os in oocyte competence,the establishment of standardized antioxidant IVM systems is critical for improving the overall success of IVP.This review focuses on the main antioxidants tested to protect oocytes against OS in IVM.

关 键 词：In vitro maturation Oocyte maturation Oxidative stress Free radicals ANTIOXIDANT Reactive oxygen species 

分 类 号：R71[医药卫生—妇产科学]