基于《黄帝内经》“骨蚀”探析药物相关性颌骨坏死的中医病机  

Analysis of the Traditional Chinese Medicine Pathogenesis of Medication-Related Osteonecrosis of the Jaw Based on"Bone Erosion"in Huangdi Neijing

作　　者：李萌菲 张馨予 潘彦君 贾蓓[1] 徐润冰 姜苗[1,2] LI Mengfei;ZHANG Xinyu;PAN Yanjun;JIA Bei;XU Runbing;JIANG Miao(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;School of Life Sciences,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学生命科学学院,北京100029

出　　处：《中医药导报》2023年第12期185-189,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中央高校基本科研业务费专项资金资助项目(2022-JYB-JBZR-022)。

摘　　要：溯源《黄帝内经》中“骨蚀”,阐释“虚邪”致病内涵,分析“骨蚀”与药物相关性颌骨坏死在病因病机、临床表现上的相关性,并结合抗骨吸收药物和抗血管生成药物药邪致病的特性,将药物相关性颌骨坏死的中医病机归纳为药邪积聚、肾精亏虚、脾胃虚弱,分别从正虚、邪实两方面探析药物相关性颌骨坏死的发生、发展过程。This article traced the origin of"bone erosion"in the Huangdi Neijing,explained the pathogenic connotation of"deficiency pathogen",analyzed the correlation between"bone erosion"and medication-related osteonecrosis of the jaw in etiology,pathogenesis and clinical manifestations,combined with the characteristics of anti-bone resorption drugs and anti-angiogenesis drugs.The traditional Chinese medicine pathogenesis of medication-related osteonecrosis of the jaw was summarized as accumulation of drug pathogens,deficiency of kidney essence and weakness of spleen and stomach,and the occurrence and development of medication-related osteonecrosis of the jaw were analyzed from two aspects of positive deficiency and evil excess.

关 键 词：药物相关性颌骨坏死 骨蚀 虚邪 药邪 《黄帝内经》 病机 

分 类 号：R274.9[医药卫生—中西医结合]