水杨醛缩3,4,6-三甲氧基苯甲酰肼铜(Ⅱ)配合物的合成及表征  

Synthesis and Characterization of Copper(II)complexes of 3,4,6-Trimethoxybenzoyl Hydrazide with Salicylaldehyde

作　　者：李云行 李洪雷[1] 刘冲冲 吴云[2] 赵军军 侍慧慧 Li Yunxing;Li Honglei;Liu Chongchong;Wu Yun;Zhao Junjun;Shi Huihui(Kangda College of Nanjing Medical University,Lianyungang,222000;Jiangsu Kangyuan Pharmaceutical Co.,Ltd.,Lianyungang 222000;Jiangsu Haosen Pharmaceutical Group Co.,Ltd.,Lianyungang 222000,China)

机构地区：[1]南京医科大学康达学院,江苏连云港222000 [2]江苏康缘药业股份有限公司,江苏连云港222000 [3]江苏豪森药业集团有限公司,江苏连云港222000

出　　处：《广东化工》2023年第23期36-39,共4页Guangdong Chemical Industry

基　　金：2021年度江苏省高校基础科学(自然科学)面上项目(21KJD350004);南京医科大学康达学院科研发展基金(KD2023KYJJ019)。

摘　　要：基于酰腙类及其配合物较强的生物活性及稳定性,设计了将没食子酸甲基化、酯化、酰肼,然后与水杨醛结合形成配体与氯化铜反应,形成金属螯合物的合成路线;采用紫外、红外、原子吸收分光光度法以及电喷雾质谱(ESI-MS)对金属配合物进行结构表征。结果表明,配体的紫外(UV)吸收最高峰为264 nm,另外两个特征峰为326 nm与388 nm;红外(IR:KBr,cm^(-1)):v(OH)3060,v(C=O)1601,v(N-N)2872,v(C=N)1548,v(C-N)1317。酰腙配合物的紫外(UV)吸收最高峰为273 nm,另外两个特征峰为315 nm和385 nm;红外(IR:KBr,cm^(-1)):v(C=O)1527,v(N-N)3054,v(C=N)1463,v(C-N)1339;ESI-MS:理论值为793.11,实测值为793.945;原子吸收计算值(8.01±0.5)%,实测值8.4%。经过以上分析,可推测出该金属配合物的结构为双配体结构,符合最初的预想,具有一定的科研价值。Based on the strong biological activity and stability of acylhydrazones and their complexes,a synthetic route was designed to methylate,esterify,hydrazide gallate,and then combine with salicylaldehyde to form a ligand and react with copper chloride to form a metal chelate;The metal complexes were characterized by UV,IR,AAS and ESI-MS.The results showed that the highest peak of UV absorption of the ligand was 264 nm,and the other two characteristic peaks were 326 nm and 388 nm;Infrared(IR:KBr,cm^(-1)):v(OH)3060,v(C=O)1601,v(N-N)2872,v(C=N)1548,v(C-N)1317.The highest UV absorption peak of the acylhydrazone complex is 273 nm,and the other two characteristic peaks are 315 nm and 385 nm;Infrared(IR:KBr,cm^(-1)):v(C=O)1527,v(N-N)3054,v(C=N)1463,v(C-N)1339;ESI-MS:Theoretical value is 793.11,measured value is 793.945;The calculated atomic absorption value is(8.01±0.5)%,while the measured value is 8.4%.After the above analysis,it can be inferred that the structure of the metal complex is a double ligand structure,which is in line with the initial expectation and has certain scientific research value.

关 键 词：水杨醛缩3 4 6-三甲氧基苯甲酰肼 配合物 合成 表征 

分 类 号：TQ[化学工程]