啮齿类动物抑郁相关行为学评价  

A Review of Behavioral Evaluation of Depression in Rodents

作　　者：卢宇佳 张珊 赵谦 王安娜 李丽[1] 赵静洁[1] LU Yujia;ZHANG Shan;ZHAO Qian;WANG Anna;LI Li;ZHAO Jingjie(Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院,北京100050

出　　处：《实验动物科学》2023年第6期87-93,共7页Laboratory Animal Science

基　　金：国家自然科学基金面上项目(82004109)。

摘　　要：啮齿类动物模型因其能较好地模拟人类抑郁症的一系列病理变化,是抑郁症机制及药物研究的重要载体。行为学实验广泛应用于抑郁症等神经精神疾病动物模型以及药物疗效评价。然而,抑郁相关动物行为学评价方法较为多样,各有利弊,尚没有统一的操作规范及评价标准。因此,本文旨在总结啮齿类动物抑郁相关行为学评价的实验原理、操作方法,并综述利弊及改进方法,为建立稳定可靠的动物抑郁相关行为学检测标准提供依据。Rodent animal is an important model for the study of mechanism and drug of depression because it can better simulate a series of biochemical changes of human depression.Behavioral experiments are widely used to evaluate animal models and drug efficacy of neuropsychiatric diseases such as depression.However,the animal behavior evaluation method related to depression are complex,each has its own advantages and disadvantages,and there is no unified operation standard or evaluation standard.Therefore,this paper aims to summarize the experimental principles and operational method of depression-related behavioral evaluation in rodents,and review the advantages and disadvantages as well as the improved method,so as to provide a basis for establishing stable and reliable behavioral evaluation standards for depression in animals.

关 键 词：抑郁症 啮齿类动物 行为学 

分 类 号：Q95-3[生物学—动物学]