Application of Tranexamic Acid in Shoulder Arthroscopic Surgery:A Randomised Controlled Trial  

作　　者：Tian-Ci Wang Jia-Liang Guo Qiu-Ping Tian He-Ping Deng Bing Yin Zeng Xiao Bo Lu 

机构地区：[1]Department of Orthopedic Trauma,Hebei Medical University Third Affiliated Hospital,Shijiazhuang 050051,China [2]Medical Services Section,Hebei Medical University Third Affiliated Hospital,Shijiazhuang 050051,China [3]Department of Ultrasonography,Hebei Medical University Third Affiliated Hospital,Shijiazhuang 050051,China [4]Graduate School of Hebei Medical University,Shijiazhuang 050011,China

出　　处：《Chinese Medical Sciences Journal》2023年第4期273-278,共6页中国医学科学杂志（英文版）

摘　　要：Objective To explore the optimal administration route of tranexamic acid(TXA)in shoulder arthroscopic surgery.Methods Patients undergoing arthroscopic rotator cuff repair were randomly divided into four groups:control group(without TXA treatment),intravenous group(TXA was intravenously administered 10 minutes before surgery),irrigation group(TXA was added to the irrigation fluid during subacromial decompression and acromioplasty),and intravenous plus irrigation group(TXA was applied both intravenously and via intra-articular irrigation).The primary outcome was visual clarity assessed with visual analog scale(VAS)score,and the secondary outcomes included irrigation fluid consumption and time to subacromial decompression and acromioplasty procedure.Results There were 134 patients enrolled in the study,including 33 in the control group,35 in the intravenous group,32 in the irrigation group,and 34 in the intravenous plus irrigation group.The median and interquartile range of VAS scores for the intravenous,irrigation,and intravenous plus irrigation groups were 2.70(2.50,2.86)(Z=-3.677,P=0.002),2.67(2.50,2.77)(Z=-3.058,P<0.001),and 2.91(2.75,3.00)(Z=-6.634,P<0.001),respectively,significantly higher than that of the control group[2.44(2.37,2.53)].Moreover,the control group consumed more irrigation fluid than the intravenous group,irrigation group,and intravenous plus irrigation group(all P<0.05).The intravenous plus irrigation group consumed less irrigation fluid than either the intravenous group or the irrigation group(both P<0.001).There was no difference in subacromial decompression and acromioplasty operative time among the four groups.Conclusion TXA applied both topically and systematically can improve intraoperative visual clarity,and the combined application is more effective.

关 键 词：tranexamic acid shoulder arthroscopic surgery visual clarity rotator cuff tear administration route 

分 类 号：R687.4[医药卫生—骨科学]