硝苯地平联合拉贝洛尔治疗妊娠期高血压的效果及对血清ALP、LAP水平和凝血功能的影响  

Effect of nifedipine combined with labetalol on gestational hypertension and its influence on serum level of ALP and LAP and coagulation function

作　　者：姚娜 何战强 Yao Na;He Zhanqiang(Department of Obstetrics and Gynecology,the First People’s Hospital of Zhumadian,Zhumadian 463000,China)

机构地区：[1]驻马店市第一人民医院妇产科,驻马店463000

出　　处：《中国实用医刊》2023年第21期110-113,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨硝苯地平联合拉贝洛尔治疗妊娠期高血压的临床效果及对患者血清碱性磷酸酶(ALP)、亮氨酸氨基肽酶(LAP)水平和凝血功能的影响。方法抽取2021年3月至2022年4月驻马店市第一人民医院收治的妊娠期高血压患者104例,按随机数字表法分为对照组和观察组,每组52例。对照组予以拉贝洛尔治疗,观察组予以硝苯地平联合拉贝洛尔治疗,两组均持续治疗10 d。比较两组患者的临床疗效、血清ALP和LAP水平、血压水平、凝血功能[凝血酶时间(TT)及凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)及降钙素原(FIB)]、妊娠结局及不良反应发生情况。结果观察组临床总有效率(94.23%,49/52)高于对照组(78.85%,41/52),差异有统计学意义(P<0.05)。治疗后,观察组血清LAP为(12.86±3.02)U/L,ALP为(265.69±50.26)U/L,高于对照组的(11.53±2.81)、(230.71±40.38)U/L,P<0.05;观察组舒张压为(84.61±6.29)mmHg(1 mmHg=0.133 kPa),收缩压为(105.44±7.82)mmHg,低于对照组的(92.14±7.65)、(115.51±8.43)mmHg,P<0.05;观察组PT、APTT、TT均长于对照组,FIB低于对照组(P<0.05);观察组不良妊娠结局发生率为3.85%(2/52),低于对照组的19.23%(10/52),P<0.05;两组不良反应发生率比较,差异未见统计学意义(P>0.05)。结论硝苯地平联合拉贝洛尔治疗妊娠期高血压效果良好,能够调节患者的血清ALP、LAP水平,降低血压水平,改善凝血功能及不良妊娠结局,减少不良反应发生率。Objective To investigate the effect of nifedipine combined with labetalol on gestational hypertension and its influence on serum alkaline phosphatase(ALP)level,leucine aminopeptidase(LAP)level,and blood coagulation function.Methods A total of 104 patients with gestational hypertension admitted to the First People’s Hospital of Zhumadian from March 2021 to April 2022 were selected,and they were divided into control group and observation group by random number table method,with 52 cases in each group.The control group was treated with labetalol,and the observation group was treated with nifedipine combined with labetalol.Both groups were treated for 10 days continuously.The clinical efficacy,levels of serum ALP and LAP,blood pressure level,coagulation function,which was assessed by thrombin time(TT),prothrombin time(PT),activeated partial thromboplasting time(APTT)and fibrinogen(FIB),pregnancy outcomes,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group(94.23%,49/52)was higher than that of the control group(78.85%,41/52),with a statistically significant difference(P<0.05).After treatment,the levels of serum LAP and ALP in the observation group were(12.86±3.02)U/L and(265.69±50.26)U/L,respectively,which were higher than the(11.53±2.81)U/L and(230.71±40.38)U/L in the control group(P<0.05).The diastolic blood pressure and systolic blood pressure in the observation group were(84.61±6.29)mmHg 1 mmHg=0.133 kPa and(105.44±7.82)mmHg,respectively,which were lower than the(92.14±7.65)mmHg and(115.51±8.43)mmHg in the control group(P<0.05),correspondingly.The PT,APTT,and TT in the observation group were all longer than those in the control group,while the FIB was lower than that in the control group(P<0.05).The incidence of adverse pregnancy outcomes in the observation group(3.85%,2/52)was lower than that in the control group(19.23%,10/52),with a statistically significant difference(P<0.05).There was no statistically significant difference

关 键 词：妊娠 高血压 硝苯地平 拉贝洛尔 凝血功能 妊娠结局 不良反应 

分 类 号：R714.246[医药卫生—妇产科学]