生物纳米材料作为药物递送系统用于骨质疏松治疗的研究进展  

Advances in the study of bio-nanomaterials as drug delivery systems for the treatment of osteoporosis

作　　者：何海荣 黎松波 黎建文[2] 尹煜超[2] 王政纬 HE Hai-rong;LI Song-bo;LI Jian-wen;YIN Yu-chao;WANG Zheng-wei(Guangdong Medical University,Zhanjiang 524023,China;Dongguan People's Hospital,Dongguan 523069,China)

机构地区：[1]广东医科大学,广东湛江524023 [2]东莞市人民医院,广东东莞523069

出　　处：《广东医科大学学报》2023年第6期700-704,共5页Journal of Guangdong Medical University

基　　金：广东省基础与应用基础研究基金项目(粤莞联合基金—地区培育项目)(2021B1515140056);东莞市社会发展科技项目(重点)(20221800906282)。

摘　　要：骨质疏松(OP)是一种全身性骨病。目前的治疗药物由于疗程长、患者依从性差、不良反应等因素,导致治疗效果不理想。生物纳米材料作为一种新的药物递送体系已被应用于靶向治疗OP。该文就多种可实现骨靶向治疗的生物纳米材料的生物特性、缓释模式等特征,及其在骨质疏松治疗中的应用前景作一综述。Osteoporosis is a systemic bone disease.The therapeutic efficacy of current drugs is not satisfactory due to the long course of treatment,poor patient compliance,and adverse reactions.As new drug delivery systems,biomaterials have been applied to target for osteoporosis.This article reviews the biological characteristics and sustained release modes of various bone-targeted biological nanomaterials and their application prospects in the treatment of osteoporosis.

关 键 词：骨质疏松 骨再生 纳米材料 

分 类 号：R681[医药卫生—骨科学]