纳布啡的围术期应用新进展(综述)  

New progress in clinical application of nalbuphine hydrochloride in perioperative

作　　者：吴昊 杨恒[2] WU Hao;YANG Heng(Fuyang Women and Children's Hospital,Fuyang 236000,Anhui;Hefei First People's Hospital,Hefei 230091,Anhui)

机构地区：[1]阜阳市妇女儿童医院麻醉科,安徽阜阳236000 [2]合肥市第一人民医院南区(滨湖医院)麻醉科,安徽合肥230091

出　　处：《安徽医专学报》2023年第6期46-48,共3页Journal of Anhui Medical College

摘　　要：纳布啡是一种阿片受体的激动-拮抗药,对k受体发挥激动作用,对μ受体发挥拮抗作用,可同时与阿片受体μ、K和相结合,因此同时具有镇静镇痛以及呼吸抑制的作用。纳布啡的镇痛效果与吗啡相当,且其成瘾性比吗啡明显减小,临床上可用于中度至重度疼痛的治疗以及预防。儿受体呈拮抗作用使得纳布啡的呼吸抑制、恶心呕吐、瘙痒等发生率较吗啡明显降低。纳布啡代谢途径较为特殊,其唯一代谢场所在肝脏,排泄途径主要是肠道,极少一部分通过肾脏排泄,其对消化系统和肾功能的不良影响较小,目前临床上少有报道,相较于吗啡及非留体镇痛药具有明显的优点。该文就纳布啡在围术期应用新进展进行综述。Nalbuphine is an agonist-antagonist at opioid receptors,acting as an agonist at k-receptors and an antagonist atμ-receptors,binding to opioid receptorsμ,k and at the same time,and thus having both sedative and analgesic as well as respiratory depressant effects.The analgesic effect of The analgesic effect of nalbuphine is comparable to that of morphine,and its addictiveness is significantly reduced compared with that of morphine,so it can be used for the treatment of moderate to severe pain as well as for prophylaxis.μReceptor antagonism makes nalbuphine's incidence of respiratory depression,nausea and vomiting,and itchiness significantly reduced compared with that of morphine.The metabolic pathway of nalbuphine is relatively special.Its only metabolic site is in the liver.Its excretion pathway is mainly the intestine,and a very small part of it is excreted through the kidneys.Its adverse effects on the digestive system and renal function are relatively small.There are currently few clinical reports.Compared with morphine and non-steroidal analgesics,it has obvious advantages.This article reviews the recent advances in the application of nalbuphine in perioperative analgesia.

关 键 词：纳布啡 镇痛 镇静 

分 类 号：R971.2[医药卫生—药品]