DNA-Polyelectrolyte Composite Responsive Microparticles for Versatile Chemotherapeutics Cleaning  

作　　者：Chong Wang Jiali Wang Zhuohao Zhang Qiao Wang Luoran Shang 

机构地区：[1]Shanghai Xuhui Central Hospital,Zhongshan-Xuhui Hospital,and the Shanghai Key Laboratory of Medical Epigenetics,the International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical Sciences,Fudan University,Shanghai,200032,China

出　　处：《Research》2023年第4期349-359,共11页研究（英文）

基　　金：This work was supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(22002018);the Innovative Research Team of High-level Local University in Shanghai,and the Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning.

摘　　要：Drug therapy is among the most widely used methods in disease treatment.However,there remains a trade-off problem between drug dosage and toxicity.Blood purification by adsorption of excessive drugs during clinical treatment could be a solution for enhancing therapeutic efficacy while maintaining normal body function.Here,inspired by the intrinsic action mechanism of chemotherapeutic agents in targeting DNA in the cell nucleus,we present DNA-polyelectrolyte composite responsive microparticles for chemotherapeutics cleaning.The presence of DNA in the microparticles enabled the adsorption of multiple common chemotherapy drugs.Moreover,the microparticles are endowed with a porous structure and a photothermal-responsive ability,both of which contribute to improved adsorption by enhancing the contact of the microparticles with the drug solution.On the basis of that,the microparticles are integrated into a herringbone-structured microfluidic chip.The fluid mixing capacity and the enhanced drug cleaning efficiency of the microfluidic platform are validated on-chip.These results indicate the value of the DNA-polyelectrolyte composite responsive microparticles for drug capture and blood purification.We believe the microparticle-integrated microfluidic platform could provide a solution for settling the dosage-toxicity trade-off problems in chemotherapy.

关 键 词：DOSAGE drugs chemotherapy 

分 类 号：R96[医药卫生—药理学]