Reconfigurable Vortex-like Paramagnetic Nanoparticle Swarm with Upstream Motility and High Body-length Ratio Velocity  

作　　者：Luyao Wang Han Gao Hongyan Sun Yiming Ji Li Song Lina Jia Chutian Wang Chan Li Deyuan Zhang Ye Xu Huawei Chen Lin Feng 

机构地区：[1]School of Mechanical Engineering and Automation,Beihang University,Beijing 100191,China [2]Beijing Advanced Innovation Center for Biomedical Engineering,Beihang University,Beijing 100191,China [3]Center of Soft Matter Physics and Its Applications,Beihang University,Beijing 100191,China.

出　　处：《Research》2023年第4期361-377,共17页研究（英文）

基　　金：This work was supported by the National Key R&D Program of China(Grant No.2022YFF1502000);Beijing Municipal Fund for Distinguished Young Scholars(Grand No.JQ22022).

摘　　要：Drug delivery systems with high-targeted doses can minimize excipients,reduce side effects,and improve efficacy.Human blood circulation is a complex circulatory system,and the motion control of microrobots in the static flow field in vitro is completely different from in vivo.How to achieve precise counterflow motion for targeted drug delivery without vascular blockage and immune rejection is the biggest challenge for micro-nano robots.Here,we propose a control method that enables vortex-like paramagnetic nanoparticle swarm(VPNS)to move upstream against the flow.By mimicking the clustering motion of wild herring schools and the rolling of leukocytes,VPNS are incredibly stable even when subjected to high-intensity jet impacts in the blood environment,can travel upstream,anchor at the target location,and dissipate when the magnetic field is withdrawn,which greatly reduces the risk of thrombosis.VPNS can also upstream along the vessel wall without an additional energy source and has a marked targeted therapeutic effect on subcutaneous tumors.

关 键 词：magnetic VELOCITY UPSTREAM 

分 类 号：TB383[一般工业技术—材料科学与工程]