早产儿脑白质损伤啮齿类动物模型研究进展  

Research progress on rodent models for white matter injury in premature infants

作　　者：李悦绮 张智威 林振浪[2] 方明楚 Li Yueqi;Zhang Zhiwei;Lin Zhenlang;Fang Mingchu(Second Clinical Medical College,Wenzhou Medical University,Wenzhou 325006,China;Department of Neonatology,the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou 325027,China)

机构地区：[1]温州医科大学第二临床医学院,温州325006 [2]温州医科大学附属第二医院育英儿童医院新生儿科,温州325027

出　　处：《中华围产医学杂志》2023年第12期1045-1050,共6页Chinese Journal of Perinatal Medicine

基　　金：浙江省自然科学基金(LQ21H040009);浙江省医药卫生科技计划(2021RC092);温州市科技局基金(Y20220007)。

摘　　要：早产儿脑白质损伤动物模型在疾病发病机制和治疗研究中至关重要。通常采用啮齿类动物建模以模拟人类早产儿脑白质损伤的病理表现。目前常用的模型包括颈总动脉血流阻断与缺氧模型、产前/生后感染模型、慢性缺氧模型、高氧暴露模型、神经兴奋毒性模型和转基因模型等。本文对以上模型建模方法及其优缺点等进行综述。Animal models play a critical role in the research on the pathogenesis and treatment of white matter injury in premature infants.Rodent modeling is often used to mimic the pathological manifestations of white matter injury in premature human infants.Currently,the most used models include the common carotid artery occlusion combined with the hypoxia model,prenatal/postpartum infection model,chronic hypoxia model,hyperoxia exposure model,neuronal excitotoxicity model,transgenic model,etc.This article reviews the modeling methods,advantages,and disadvantages of the above models.

关 键 词：脑损伤 白质 疾病模型 动物 婴儿 早产 

分 类 号：R722.6[医药卫生—儿科] R-332[医药卫生—临床医学]