小胶质细胞在脓毒症相关性脑病中的作用研究进展  

Recent advance in role of microglia in sepsis associated encephalopathy

作　　者：马思奇 殷晓宇 沈锦春 Ma Siqi;Yin Xiaoyu;Shen Jinchun(Department of Anesthesiology,Jinling Clinical Medical College of Nanjing Medical University/General Hospital of PLA Eastern Theater Command,Nanjing 210002,China)

机构地区：[1]南京医科大学金陵临床医学院(解放军东部战区总医院)麻醉科,南京210002

出　　处：《中华神经医学杂志》2023年第11期1179-1182,共4页Chinese Journal of Neuromedicine

基　　金：军队医学科技青年培育计划 (20QNPPY077)。

摘　　要：脓毒症相关性脑病(SAE)是由脓毒症引起的弥漫性脑功能障碍,临床表现以意识改变及认知障碍为特征。小胶质细胞作为脑内主要的免疫细胞,是影响SAE病程进展的重要因素,例如小胶质细胞表面受体可通过影响小胶质细胞激活而在SAE发病中起重要作用,小胶质细胞激活可通过加重神经炎症、损伤血脑屏障及突触功能参与SAE的发生发展等。本文主要围绕小胶质细胞表面受体及小胶质细胞激活在SAE发生发展中的作用机制进行综述,以期为SAE的防治提供新思路。Sepsis-associated encephalopathy(SAE)is a diffuse brain dysfunction caused by sepsis,characterized by altered consciousness and cognitive dysfunction.Microglia,as the main immune cells in the brain,is an important factor in SAE progression.Microglia surface receptors play important roles in SAE pathogenesis by affecting microglia activation;in addition,microglia activation is involved in SAE by exacerbating neuroinflammation,impairing the blood-brain barrier and synaptic function.In this paper,the mechanism of microglial surface receptors and microglial activation in SAE development is reviewed to provide new ideas for SAE prevention and treatment.

关 键 词：脓毒症相关性脑病 小胶质细胞 细胞表面受体 

分 类 号：R459.7[医药卫生—急诊医学] R747.9[医药卫生—治疗学]