紫杉醇诱导的神经病理性疼痛大鼠和小鼠动物模型研究及其在中医药方面应用进展  

Animal models of paclitaxel-induced neuropathic pain in rats and mice and their application in traditional Chinese medicine

作　　者：于俊 李明珠 朴浩哲 崔颖 张立德[1] 金圣博[1] 王建波[1] YU Jun;LI Mingzhu;PIAO Haozhe;CUI Ying;ZHANG Lide;JIN Shengbo;WANG Jianbo(Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;Cancer Hospital of China Medical University,Liaoning Cancer Hospital,Shenyang 110042)

机构地区：[1]辽宁中医药大学,沈阳110032 [2]中国医科大学肿瘤医院辽宁省肿瘤医院,沈阳110042

出　　处：《中国实验动物学报》2023年第11期1447-1461,共15页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(82104838);辽宁省自然科学基金(2022-BS-059)。

摘　　要：中医药在防治化疗后所诱导的周围神经病理性疼痛(chemotherapy-induced peripheral neuropathic pain,CIPNP)方面有明确的临床疗效优势,但其具体临床应用和作用机制等仍待更深入研究和探索,因此需要探究出更精准、更符合临床疾病发生发展规律的动物模型来作为研究的媒介。此文对近几年现有紫杉醇所致的CIPNP大鼠和小鼠动物模型的建立和检测标准进行深入的梳理和探讨,及其模型在中医药防治CIPNP方面的应用价值做相关评价及阐述,以期能为今后中医药防治CIPNP的实验研究提供理论依据和参考,更加利于临床实践和推广。Traditional Chinese medicines have demonstrated clinical efficacy in preventing and treating chemotherapy-induced peripheral neuropathic pain(CIPNP).However,their specific clinical application and mechanism of action require further in-depth study and exploration.There is thus a need to develop more accurate and clinically relevant animal models that reflect the occurrence and development of human diseases as a tool for research.This review provides an in-depth analysis and discussion of the recent establishment and detection criteria of existing rat and mouse animal models of paclitaxel-induced peripheral neuropathic pain.We also evaluate and explain the application of these models for the prevention and treatment of CIPNP in traditional Chinese medicine,thus providing a theoretical basis and reference for future experimental and mechanistic research on the subject.This research will benefit clinical practice and promotion,offering valuable insights into preventing and treating CIPNP using traditional Chinese medicines.

关 键 词：紫杉醇 化疗 周围神经病理性疼痛 动物模型 中医药防治 

分 类 号：Q95-33[生物学—动物学]